Antonaci S, Stasi D, Gallitelli M, Jirillo E
Immunopharmacology. 1986 Aug;12(1):23-8. doi: 10.1016/0162-3109(86)90048-2.
Several lines of evidence point out that Salmonella minnesota R345 (Rb) possesses the capacity to adhere spontaneously to human peripheral blood lymphocytes. The binding is mediated via the lipopolysaccharide moiety of the bacterial outer membrane. In this report, we have evaluated the effects of various antibiotics on bacterial binding. Our data show that trimethoprim/sulphamethoxazole, chloramphenicol and erythromycin significantly decrease Rb binding, while gentamicin and sisomicin are without effect. Antibiotics display their inhibitory effect by acting on peripheral blood lymphocytes likely by competing with lipopolysaccharide for receptor binding capacity on lymphocyte surface.
多项证据表明，明尼苏达沙门氏菌R345（Rb）具有自发黏附人外周血淋巴细胞的能力。这种黏附是通过细菌外膜的脂多糖部分介导的。在本报告中，我们评估了各种抗生素对细菌黏附的影响。我们的数据表明，甲氧苄啶/磺胺甲恶唑、氯霉素和红霉素可显著降低Rb的黏附，而庆大霉素和西索米星则无此作用。抗生素可能通过与脂多糖竞争淋巴细胞表面的受体结合能力，作用于外周血淋巴细胞，从而发挥其抑制作用。
