Perea E J, Gutierrez de la Pena C, Oliver D A, Solorzano G, Garcia-Diaz S
Arzneimittelforschung. 1979;29(1):134-7.
A clinical and bacteriological study to evaluate the effectiveness and toxicity of sisomicin in the treatment of surgical infections is described. Fifteen patients received i.m. injections of 150 or 225 mg/day for seven days. The daily doses was divided into three applications. The mean serum levels at the first hour were 5.26 +/- 2.41 microgram/ml and at the seventh hour 1.0 +/- 1.19 microgram/ml. Similar values were determined on the seventh day of treatment with sisomicin: 6.36 +/- 2.36 microgram/ml one hour, 1.17 +/- 1.67 microgram/ml seven hours after i.m. injection. All the microorganisms isolated had MICs below the sisomicin levels measured. The clinical results were assessed as "excellent" in 11 patients. Therapeutic results were considered as "fair" in three patients. The clinical conditions of one patient affected by osteomyelitis following osteosynthesis of the femur was not improved by treatment. No side effects were observed.
本文描述了一项临床和细菌学研究，旨在评估西索米星治疗外科感染的有效性和毒性。15名患者接受了为期7天的每日150或225毫克的肌肉注射。每日剂量分为三次给药。第一小时的平均血清水平为5.26±2.41微克/毫升，第七小时为1.0±1.19微克/毫升。在使用西索米星治疗的第七天测定了类似的值：肌肉注射后一小时为6.36±2.36微克/毫升，七小时后为1.17±1.67微克/毫升。所有分离出的微生物的最低抑菌浓度均低于所测的西索米星水平。11名患者的临床结果被评定为“优秀”。3名患者的治疗结果被认为“尚可”。一名因股骨骨折内固定术后发生骨髓炎的患者，治疗后临床状况未改善。未观察到副作用。
