Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Terengganu, Malaysia.
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.
Naunyn Schmiedebergs Arch Pharmacol. 2024 Apr;397(4):1919-1934. doi: 10.1007/s00210-023-02645-9. Epub 2023 Aug 18.
Cancer is a complex disease characterized by dysregulated cell growth and division, posing significant challenges for effective treatment. Hispidulin, a flavonoid compound, has shown promising biological effects, particularly in the field of anticancer research. The main objective of this study is to investigate the anticancer properties of hispidulin and gain insight into its mechanistic targets in cancer cells. A comprehensive literature review was conducted to collect data on the anticancer effects of hispidulin. In vitro and in vivo studies were analyzed to identify the molecular targets and underlying mechanisms through which hispidulin exerts its anticancer activities. Hispidulin has shown significant effects on various aspects of cancer, including cell growth, proliferation, cell cycle regulation, angiogenesis, metastasis, and apoptosis. It has been observed to target both extrinsic and intrinsic apoptotic pathways, regulate cell cycle arrest, and modulate cancer progression pathways. The existing literature highlights the potential of hispidulin as a potent anticancer agent. Hispidulin exhibits promising potential as a therapeutic agent for cancer treatment. Its ability to induce apoptosis and modulate key molecular targets involved in cancer progression makes it a valuable candidate for further investigation. Additional pharmacological studies are needed to fully understand the specific targets and signaling pathways influenced by hispidulin in different types of cancer. Further research will contribute to the successful translation of hispidulin into clinical settings, allowing its utilization in conventional and advanced cancer therapies with improved therapeutic outcomes and reduced side effects.
癌症是一种以细胞生长和分裂失调为特征的复杂疾病，对有效治疗构成了重大挑战。山金车素，一种黄酮类化合物，具有很有前景的生物学效应，特别是在抗癌研究领域。本研究的主要目的是研究山金车素的抗癌特性，并深入了解其在癌细胞中的作用机制靶点。进行了全面的文献综述，以收集有关山金车素抗癌作用的数据。分析了体外和体内研究，以确定山金车素发挥抗癌活性的分子靶点和潜在机制。山金车素对癌症的各个方面都有显著影响，包括细胞生长、增殖、细胞周期调控、血管生成、转移和细胞凋亡。已经观察到它可以靶向外在和内在的凋亡途径，调节细胞周期停滞，并调节癌症进展途径。现有文献强调了山金车素作为一种有效的抗癌剂的潜力。山金车素作为癌症治疗的治疗剂具有很大的潜力。它诱导细胞凋亡和调节癌症进展中涉及的关键分子靶点的能力使其成为进一步研究的有价值的候选物。需要进行更多的药理学研究，以充分了解山金车素在不同类型癌症中影响的特定靶点和信号通路。进一步的研究将有助于成功地将山金车素转化为临床应用，允许其在常规和先进的癌症治疗中使用，以改善治疗效果并减少副作用。
