BRAF V600E 与朗格汉斯细胞组织细胞增生症成人中第二癌症的更高发生率相关。
BRAF V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis.
机构信息
Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Division of Hematology, Mayo Clinic, Rochester, MN.
出版信息
Blood. 2023 Nov 2;142(18):1570-1575. doi: 10.1182/blood.2023021212.
Abstract
In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.
摘要
在这项回顾性研究中，BRAF 突变状态与 156 例朗格汉斯细胞组织细胞增生症成人患者的疾病范围或（无事件）生存无关。BRAFV600E 与第二恶性肿瘤的发生率增加相关，这些肿瘤通常包括血液系统癌症，可能与克隆相关。
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