Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
Pathol Res Pract. 2023 Sep;249:154763. doi: 10.1016/j.prp.2023.154763. Epub 2023 Aug 14.
Merkel cell carcinoma (MCC) is a rare, aggressive form of skin malignancy with a high recurrence commonly within two to three years of initial diagnosis. The incidence of MCC has nearly doubled in the past few decades. Options for diagnosing, assessing, and treating MCC are limited. MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that play an important role in controlling many different aspects of cell biology. Many miRNAs are aberrantly expressed in distinct types of cancer, with some serving as tumor suppressors and others as oncomiRs. Therefore, the future holds great promise for the utilization of miRNAs in enhancing diagnostic, prognostic, and therapeutic approaches for MCC. Accordingly, the goal of this article is to compile, summarize, and discuss the latest research on miRNAs in MCC, highlighting their potential clinical utility as diagnostic and prognostic biomarkers.
默克尔细胞癌（Merkel cell carcinoma，MCC）是一种罕见的、侵袭性皮肤恶性肿瘤，在初始诊断后的两到三年内常有较高的复发率。在过去几十年中，MCC 的发病率几乎翻了一番。目前用于诊断、评估和治疗 MCC 的方法有限。MicroRNAs（miRNAs）是一类小的非编码 RNA 分子，在控制细胞生物学的许多不同方面发挥着重要作用。许多 miRNAs 在不同类型的癌症中表达异常，其中一些作为肿瘤抑制因子，另一些则作为癌基因 miRNA。因此，miRNAs 在增强 MCC 的诊断、预后和治疗方法方面具有广阔的应用前景。因此，本文的目的是汇总、总结和讨论关于 MCC 中 miRNAs 的最新研究，重点探讨其作为诊断和预后生物标志物的潜在临床应用价值。
