Awwad H K, el Naggar M, Mocktar N, Barsoum M
Int J Radiat Oncol Biol Phys. 1986 Aug;12(8):1329-33. doi: 10.1016/0360-3016(86)90165-3.
The mean tumor intercapillary distance (ICD) was measured in 44 patients in Stages IIB and III carcinoma of the cervix uteri using a histo-chemical procedure for staining capillary endothelial cells. A mean ICD of 304 +/- 30 microns was obtained, which was independent of the clinical stage and histological grade of differentiation. For each tumor, the proportion of ICD's greater than an arbitrarily chosen value of 300 microns (approximately twice the maximum oxygen diffusion range) was calculated using the normal frequency distribution statistics. The mean ICD and this proportion decreased progressively during the course of external beam pelvic irradiation up to a dose of 4000 cGy. The mean ICD was greater in patients who suffered local recurrence within two years than in patients whose tumors remained controlled. This applied to pre-treatment values and measurements performed after the delivery of 2000 and 4000 cGy. The proportion of ICD's greater than 300 microns showed a similar trend. No significant correlation was found between the hemoglobin concentration at time of presentation and either the mean ICD, or the probability of local control. It is proposed that ICD measurement may be a useful tool to identify subgroups of tumors where hypoxia can interfere with the effectiveness of radiotherapy.
采用组织化学方法对宫颈内皮细胞进行染色，测量了44例IIB期和III期子宫颈癌患者的肿瘤毛细血管间平均距离（ICD）。测得平均ICD为304±30微米，这与临床分期和组织学分化程度无关。对于每例肿瘤，使用正态频率分布统计方法计算ICD大于任意选定值300微米（约为最大氧扩散范围的两倍）的比例。在盆腔外照射至4000 cGy的过程中，平均ICD和该比例逐渐降低。在两年内出现局部复发的患者中，平均ICD高于肿瘤得到控制的患者。这适用于治疗前的值以及给予2000 cGy和4000 cGy照射后的测量值。ICD大于300微米的比例也呈现类似趋势。就诊时的血红蛋白浓度与平均ICD或局部控制概率之间未发现显著相关性。有人提出，ICD测量可能是一种有用的工具，用于识别缺氧可能干扰放射治疗效果的肿瘤亚组。
