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子宫颈癌的血管生成与放射可治愈性。一项回顾性研究。

Vascularization and radiocurability in cancer of the uterine cervix. A retrospective study.

作者信息

Siracká E, Siracký J, Pappová N, Révész L

出版信息

Neoplasma. 1982;29(2):183-8.

PMID:7110445
Abstract

The proportion of vascular elements in relation to the parenchymal and stromal components was determined by morphometric analysis of the histologic preparations from biopsies of uterine cervix cancers. In all cases, the material was obtained from tumors in Stages Ib and IIa before any therapy was initiated. In the 23 cases in which radiation treatment of the lesions resulted in a survival longer than 5 years, the proportion of blood vessels in the neoplastic tissue was found to be larger, and especially the stromal components were richer in vascular elements than in the 22 cases in which survival was shorter than 5 years. It was concluded that vascular density at least in cervical cancers of the stages studied can be a diagnostic parameter of a prognostic value as well as of a therapeutic usefulness.

摘要

通过对子宫颈癌活检组织学切片进行形态计量分析,确定血管成分与实质及间质成分的比例。所有病例均取自Ib期和IIa期肿瘤,且未进行任何治疗。在23例经放射治疗后存活超过5年的病例中,发现肿瘤组织中的血管比例更大,尤其是间质成分中的血管成分比22例存活时间短于5年的病例更丰富。得出结论,至少在所研究阶段的宫颈癌中,血管密度可作为一个具有预后价值和治疗用途的诊断参数。

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Vascularization and radiocurability in cancer of the uterine cervix. A retrospective study.子宫颈癌的血管生成与放射可治愈性。一项回顾性研究。
Neoplasma. 1982;29(2):183-8.
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引用本文的文献

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Tumour vascularity is a significant prognostic factor for cervix carcinoma treated with radiotherapy: independence from tumour radiosensitivity.肿瘤血管生成是宫颈癌放疗的一个重要预后因素:与肿瘤放射敏感性无关。
Br J Cancer. 1999 Sep;81(2):354-8. doi: 10.1038/sj.bjc.6690700.
2
Angiogenesis is associated with vascular endothelial growth factor expression in cervical intraepithelial neoplasia.血管生成与宫颈上皮内瘤变中血管内皮生长因子的表达相关。
Br J Cancer. 1997;76(11):1410-5. doi: 10.1038/bjc.1997.571.
3
Oxygen tension and vascular density in human cervix carcinoma.
人宫颈癌中的氧张力与血管密度
Br J Cancer. 1996 Nov;74(10):1559-63. doi: 10.1038/bjc.1996.589.
4
Vascularization and curability of stage III and IV nasopharyngeal tumors.III期和IV期鼻咽癌的血管生成与可治愈性
J Cancer Res Clin Oncol. 1988;114(3):321-3. doi: 10.1007/BF00405843.
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The vascular architecture of human xenotransplanted tumors: histological, morphometrical, and ultrastructural studies.人异种移植肿瘤的血管结构:组织学、形态计量学及超微结构研究
J Cancer Res Clin Oncol. 1990;116(5):517-24. doi: 10.1007/BF01613005.
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Changes in tumour morphology with alterations in oxygen availability: further evidence for oxygen as a limiting substrate.肿瘤形态随氧供应变化而改变:氧作为限制底物的进一步证据。
Br J Cancer. 1991 Jul;64(1):54-8. doi: 10.1038/bjc.1991.238.