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在病理服务获取有限的国家中淋巴瘤诊断、预后及治疗监测的未来。

The future of lymphoma diagnosis, prognosis, and treatment monitoring in countries with limited access to pathology services.

作者信息

Chamba Clara, Mawalla William

机构信息

Department of Hematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

Department of Hematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

出版信息

Semin Hematol. 2023 Sep;60(4):215-219. doi: 10.1053/j.seminhematol.2023.07.004. Epub 2023 Aug 1.

Abstract

The world is moving towards precision medicine for cancer. This movement goes hand in hand with the development of newer advanced technologies for early, precise diagnosis of cancer and personalized treatment plans with fewer adverse effects for the patient. Liquid biopsy is one such advancement. At the same time, it has the advantage of minimal invasion and avoids serial invasive biopsies. In countries with limited access to pathology services, such as sub-Saharan Africa, liquid biopsy may provide an opportunity for early detection and prognostication of lymphoma. We discuss the current diagnostic modalities for lymphoma, highlighting the existing challenges with tissue biopsy, and how feasible it is for countries with limited pathology resources to leverage advancements made in the clinical application of liquid biopsy to improve lymphoma care.

摘要

世界正朝着癌症的精准医疗迈进。这一趋势与更新的先进技术的发展齐头并进,这些技术用于癌症的早期精准诊断以及制定对患者副作用更小的个性化治疗方案。液体活检就是这样一项进展。同时,它具有微创的优势,避免了系列侵入性活检。在诸如撒哈拉以南非洲等病理服务获取有限的国家,液体活检可能为淋巴瘤的早期检测和预后评估提供机会。我们讨论了淋巴瘤的当前诊断方式,强调了组织活检存在的挑战,以及病理资源有限的国家利用液体活检临床应用方面的进展来改善淋巴瘤治疗的可行性。

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