Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA.
Department of Neonatology, Intermountain Healthcare, Murray, UT, USA.
J Perinatol. 2023 Nov;43(11):1368-1373. doi: 10.1038/s41372-023-01751-z. Epub 2023 Aug 18.
To compare serum ferritin and RET-He values among extremely low gestational age neonates ELGANs with other markers of iron-deficient erythropoiesis.
This is a secondary analysis of the NICHD Darbepoetin Trial. Study data from placebo recipients who had a serum ferritin, a RET-He, and a mean corpuscular volume (MCV) measurement within a 24-hour period were analyzed for correlation.
Mixed linear regression models showed no association between ferritin and RET-He at both early (β = 0.0016, p = 0.40) and late (β = -0.0001, p = 0.96) time points. Positive associations were observed between RET-He and MCV at baseline, early, and late time points (p < 0.01, =0.01, <0.001, respectively), while ferritin was not associated with MCV at any time point.
Our study shows that RET-He is better correlated with MCV as a marker of iron-limited erythropoiesis than ferritin. The results suggest that ferritin is limited as a marker of iron sufficiency in premature infants.
FDA IND Number 100138; ClinicalTrials.gov number NCT03169881; NRN ID number NICHD-NRN-0058 (Darbe).
比较极低出生体重儿（ELGANs）的血清铁蛋白和 RET-He 值与其他缺铁性红细胞生成标志物。
这是 NICHD 达贝泊汀试验的二次分析。对接受安慰剂治疗的研究对象的数据进行分析，这些对象在 24 小时内有血清铁蛋白、RET-He 和平均红细胞体积（MCV）测量值。
混合线性回归模型显示，在早期（β=0.0016，p=0.40）和晚期（β=-0.0001，p=0.96）时间点，铁蛋白和 RET-He 之间均无相关性。在基线、早期和晚期时间点，RET-He 与 MCV 之间存在正相关（p<0.01、=0.01、<0.001，分别），而铁蛋白与 MCV 之间任何时间点均无相关性。
我们的研究表明，RET-He 与 MCV 作为缺铁性红细胞生成的标志物的相关性优于铁蛋白。结果表明，铁蛋白作为早产儿铁充足的标志物是有限的。
FDA IND 编号 100138；ClinicalTrials.gov 编号 NCT03169881；NRN ID 编号 NICHD-NRN-0058（Darbe）。
