Division of Neonatology, University of Washington/Seattle Children's Hospital, Seattle, WA, USA.
Department of Biostatistics, University of Washington, Seattle, WA, USA.
J Perinatol. 2019 Sep;39(9):1268-1274. doi: 10.1038/s41372-019-0434-6. Epub 2019 Jul 26.
The reticulocyte index reticulocyte hemoglobin equivalent (Ret-He) was evaluated as a marker of iron status.
This is a retrospective cohort study of all infants admitted to the University of Washington Neonatal Intensive Care Unit, who received Ret-He measurements as part of routine care within the first 120 days of life.
A total of 730 Ret-He measurements from 249 infants were analyzed (median gestational age at birth 32.1 weeks; 49 infants <28 weeks and 200 ≥28 weeks). Initial Ret-He measurements were lower in infants <28 weeks (28.24 vs. 33.34 pg). Ret-He values initially decreased, then slowly increased. Infants received an average of 3.9, 6.5, and 8.2 mg/kg/day of enteral iron sulfate at 30, 60, and 90 days, respectively.
Ret-He values showed a slow uptrend with enteral iron supplementation following an initial decrease, suggesting that neonates are able to improve their iron sufficiency status with supplementation.
网织红细胞指数网织红细胞血红蛋白当量（Ret-He）被评估为铁状态的标志物。
这是一项对所有在华盛顿大学新生儿重症监护病房住院的婴儿进行的回顾性队列研究，这些婴儿在生命的头 120 天内接受了 Ret-He 测量，作为常规护理的一部分。
对 249 名婴儿的 730 次 Ret-He 测量进行了分析（出生时的中位胎龄为 32.1 周；49 名婴儿<28 周，200 名婴儿≥28 周）。<28 周的婴儿初始 Ret-He 测量值较低（28.24 对 33.34pg）。Ret-He 值最初下降，然后缓慢上升。婴儿在 30、60 和 90 天分别接受了平均 3.9、6.5 和 8.2mg/kg/天的硫酸亚铁肠内铁补充。
Ret-He 值在初始下降后随着肠内铁补充呈现缓慢上升趋势，表明新生儿能够通过补充来改善其铁充足状态。
