Psychology and Neuroscience of Cognition Unit, Université de Liège, Place Des Orateurs, 1, B33 4000, Liège, Belgium.
University Psychology and Speech Therapy Clinic, CPLU, Université de Liège, Liège, Belgium.
BMC Neurol. 2023 Aug 18;23(1):307. doi: 10.1186/s12883-023-03346-9.
Cognitive difficulties are a frequent complaint in long COVID and persist for more than a year post- infection. There is a lack of evidence-based data on effective intervention strategies. Non-pharmacological intervention programs that are used with other neurological populations have not yet been the subject of controlled trials. COVCOG is a multicentric, randomized trial comparing cognitive intervention and a cognitive-behavioural counselling.
METHODS/DESIGN: Patients with long covid are selected and recruited at least three months post-infection. Patients are randomised in a 1:1 ratio into the cognitive (neuropsychological psychoeducation) and affective (emotion management with cognitive-behavioural counselling) intervention arms. The inclusion of 130 patients is planned. The cognitive intervention includes psycho-educational modules on fatigue and sleep, attention and working memory, executive functions and long-term memory. The affective intervention includes modules on emotion recognition and communication, uncertainty management and behavioral activation. The main objective is to reduce cognitive complaints 2 months after the intervention. A Follow-up is also planned at 8 months.
Given the long-term effects of Covid on cognition and the negative effects of cognitive impairment on quality of life and social participation, it is important to determine whether low-dose, non-pharmacological interventions can be effective. The trial will determine which of the usual types of intervention is the most effective.
Clinicaltrials.gov Number: NCT05167266 (21/12/ 2021).
认知障碍是长新冠的常见主诉，并且在感染后持续一年以上。目前缺乏有效的干预策略的循证数据。尚未对用于其他神经科人群的非药物干预方案进行对照试验。COVCOG 是一项多中心、随机试验，比较认知干预和认知行为咨询。
方法/设计：在感染后至少三个月时选择和招募长新冠患者。患者以 1:1 的比例随机分为认知（神经心理学心理教育）和情感（情绪管理与认知行为咨询）干预组。计划纳入 130 名患者。认知干预包括疲劳和睡眠、注意力和工作记忆、执行功能和长期记忆的心理教育模块。情感干预包括情绪识别和沟通、不确定性管理和行为激活模块。主要目标是在干预后 2 个月减少认知主诉。还计划在 8 个月时进行随访。
鉴于新冠对认知的长期影响以及认知障碍对生活质量和社会参与的负面影响，确定低剂量非药物干预是否有效非常重要。该试验将确定哪种常规干预类型最有效。
Clinicaltrials.gov 编号：NCT05167266（2021 年 12 月 21 日）。
