哌拉西林增强细菌细胞对5-氟尿嘧啶的摄取。
Enhancement of 5-fluorouracil uptake into the bacterial cell by piperacillin.
作者信息
Takahata M, Yamashiro Y, Yotsuji A, Fukuoka Y, Yasuda T, Saikawa I, Ueda Y
出版信息
J Antibiot (Tokyo). 1986 Aug;39(8):1167-71. doi: 10.7164/antibiotics.39.1167.
The antibacterial activity of 5-fluorouracil, an antineoplastic agent, was found to be enhanced by piperacillin, a beta-lactam antibiotic, resulting in a synergism. It was considered that the synergism was caused by an increase of 5-fluorouracil uptake into the bacterial cell. On the other hand, amount of piperacillin bound to penicillin binding protein (PBP) did not change when 5-fluorouracil was added. The morphological change of the cell was due to the 5-fluorouracil when synergism appeared between 5-fluorouracil and piperacillin.
抗肿瘤药物5-氟尿嘧啶的抗菌活性被β-内酰胺类抗生素哌拉西林增强，从而产生协同作用。据认为，这种协同作用是由细菌细胞对5-氟尿嘧啶摄取量的增加引起的。另一方面，添加5-氟尿嘧啶后，与青霉素结合蛋白（PBP）结合的哌拉西林量没有变化。当5-氟尿嘧啶和哌拉西林之间出现协同作用时，细胞的形态变化是由5-氟尿嘧啶引起的。
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