肿瘤微环境中的可变剪接事件和功能：新的机遇和挑战。

Alternative splicing events and function in the tumor microenvironment: New opportunities and challenges.

机构信息

Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang 110122, PR China.

Department of thoracic surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.

出版信息

Int Immunopharmacol. 2023 Oct;123:110718. doi: 10.1016/j.intimp.2023.110718. Epub 2023 Aug 17.

DOI:10.1016/j.intimp.2023.110718

PMID:37597404

Abstract

Alternative splicing controls gene expression at the transcriptional level, producing structurally and functionally distinct protein heterodimers. Aberrant alternative splicing greatly affects cell development and plays an important role in the invasion and metastasis of many types of cancer. Recently, it has been shown that alternative splicing can alter the tumor microenvironment and regulate processes such as remodeling, immunity, and inflammation in the tumor microenvironment. However, there is no comprehensive literature review of the complex relationship between alternative splicing and the tumor microenvironment. Therefore, this review aims to collect all the latest data on this topic and provide a new perspective on the therapeutic and potential prognostic markers of cancer.

摘要

可变剪接在转录水平控制基因表达，产生结构和功能不同的蛋白质异源二聚体。异常的可变剪接极大地影响细胞发育，并在许多类型的癌症的侵袭和转移中发挥重要作用。最近，已经表明可变剪接可以改变肿瘤微环境，并调节肿瘤微环境中的重塑、免疫和炎症等过程。然而，目前还没有关于可变剪接与肿瘤微环境之间复杂关系的全面文献综述。因此，本综述旨在收集关于这一主题的所有最新数据，并为癌症的治疗和潜在预后标志物提供新的视角。