Universidade Federal da Paraíba, Departamento de Nutrição, João Pessoa, PB, Brazil.
Universidade Federal da Paraíba, Departamento de Fisiologia e Patologia, João Pessoa, PB, Brazil.
J Pediatr (Rio J). 2024 Jan-Feb;100(1):74-80. doi: 10.1016/j.jped.2023.07.003. Epub 2023 Aug 16.
Evaluate autonomic function and low-grade inflammation and characterize the correlation between these variables in schoolchildren with obesity living in the Brazilian northeast region.
84 children with obesity and 41 with normal weight were included in this cross-sectional study. Anthropometry, body composition, blood pressure (BP), inflammatory biomarkers, and heart rate variability (HRV) indexes were analyzed in children aged 7 to 11 years.
children with obesity had increased systolic (p = 0.0017) and diastolic (p = 0.0131) BP and heart rate (p = 0.0022). The children with obesity displayed significantly lower SDNN, RMSSD, NN50, HF (ms), HF (nu), SD1, SD2, and higher LF (ms), LF (nu), LF/HF, SD1/SD2, DFA-α1, and DFA-α2, compared to normal weight. A lower and higher capacity for producing IL-10 (p = 0.039) and IL-2 (p = 0.009), respectively, were found in children with obesity compared to children with normal weight. Although IL-2, IL-4 and IL17A did not correlate with HRV parameters, IL-6 was positively correlated with SDNN, LF (ms) and SD2, TNF-α was positively correlated with LF/HF and SD1/SD2 ratio, and IFN-γ was positively correlated with SDNN, RMMSSD, NN50, LF (ms), HF (ms), SD1, and SD2.
The findings suggest that children with obesity have impaired autonomic function and systemic low-grade inflammation compared to children within the normal weight range, the inflammatory biomarkers were correlated with HRV parameters in schoolchildren living in the northeastern region of Brazil.
评估肥胖儿童的自主神经功能和低度炎症，并描述这些变量之间的相关性，这些儿童居住在巴西东北部地区。
本横断面研究纳入了 84 名肥胖儿童和 41 名体重正常的儿童。对 7 至 11 岁儿童的人体测量学、身体成分、血压 (BP)、炎症生物标志物和心率变异性 (HRV) 指标进行分析。
肥胖儿童的收缩压 (p=0.0017) 和舒张压 (p=0.0131) 以及心率 (p=0.0022) 均升高。与体重正常的儿童相比，肥胖儿童的 SDNN、RMSSD、NN50、HF (ms)、HF (nu)、SD1、SD2 显著降低，LF (ms)、LF (nu)、LF/HF、SD1/SD2、DFA-α1 和 DFA-α2 显著升高。与体重正常的儿童相比，肥胖儿童产生 IL-10 的能力较低 (p=0.039)，产生 IL-2 的能力较高 (p=0.009)。尽管 IL-2、IL-4 和 IL17A 与 HRV 参数无相关性，但 IL-6 与 SDNN、LF (ms) 和 SD2 呈正相关，TNF-α 与 LF/HF 和 SD1/SD2 比值呈正相关，IFN-γ 与 SDNN、RMMSSD、NN50、LF (ms)、HF (ms)、SD1 和 SD2 呈正相关。
与体重正常范围内的儿童相比，肥胖儿童的自主神经功能受损，全身低度炎症，巴西东北部地区的儿童炎症生物标志物与 HRV 参数相关。
