Department of Nutrition, Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.
Department of Physiology and Pathology, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.
Nutrients. 2024 Jul 31;16(15):2477. doi: 10.3390/nu16152477.
This study evaluated anthropometric, biochemical, and inflammatory biomarkers, as well as dietary intake in Brazilian children diagnosed with small intestinal bacterial overgrowth (SIBO) and compared them with their counterparts without SIBO.
This was a cross-sectional study with 106 children aged 7 to 10 years. A glucose-hydrogen breath test was performed to diagnose small intestinal bacterial overgrowth (SIBO). Anthropometric and dietary characteristics were assessed. Blood samples were collected and serum biochemical parameters and cytokines were measured.
The occurrence of SIBO was 13.2%. Age, BMI, BMI/age WC, BFP, sex and biochemical markers were similar between SIBO-positive and SIBO-negative children ( > 0.05). High consumption of ultra-processed foods tended to be higher in SIBO-positive compared to SIBO-negative children (47.8 ± 8.2 vs. 42.6 ± 9.5, = 0.06). Serum levels of IL-17 were higher in SIBO-positive than in SIBO-negative children [69.5 (5.4-125.7) vs. 53.4 (2.3-157.7), = 0.03], while serum levels of IL-10 were lower in SIBO-positive than in SIBO-negative children [2.3 (0.6-7.2) vs. 5.7 (0.5-30.8), = 0.04]. Finally, in a logistic regression adjusted for sex, BMI and age, consumption of ultra-processed foods ( = 0.03) and IL-6 levels ( = 0.003) were found to contribute to the occurrence of SIBO.
this study identified for the first time an occurrence of 13% of SIBO in children living in the northeastern region of Brazil and showed that consumption of ultra-processed foods and serum levels of IL-6 may influence the occurrence of the SIBO in the pediatrics population.
本研究评估了巴西患有小肠细菌过度生长（SIBO）的儿童的人体测量学、生化和炎症生物标志物以及饮食摄入量，并将其与无 SIBO 的儿童进行了比较。
这是一项横断面研究，纳入了 106 名 7 至 10 岁的儿童。通过葡萄糖-氢气呼气试验诊断小肠细菌过度生长（SIBO）。评估人体测量学和饮食特征。采集血样，测量血清生化参数和细胞因子。
SIBO 的发生率为 13.2%。SIBO 阳性和 SIBO 阴性儿童的年龄、BMI、BMI/年龄 WC、BFP、性别和生化标志物均无差异（>0.05）。SIBO 阳性儿童超加工食品的高摄入量倾向于高于 SIBO 阴性儿童（47.8±8.2 vs. 42.6±9.5，=0.06）。SIBO 阳性儿童血清 IL-17 水平高于 SIBO 阴性儿童[69.5（5.4-125.7）vs. 53.4（2.3-157.7），=0.03]，而 SIBO 阳性儿童血清 IL-10 水平低于 SIBO 阴性儿童[2.3（0.6-7.2）vs. 5.7（0.5-30.8），=0.04]。最后，在调整性别、BMI 和年龄的 logistic 回归分析中，发现超加工食品的摄入（=0.03）和 IL-6 水平（=0.003）与 SIBO 的发生有关。
本研究首次在巴西东北部地区的儿童中发现了 13%的 SIBO 发生率，并表明超加工食品的摄入和血清 IL-6 水平可能影响儿科人群 SIBO 的发生。
