Warner D O, Rehder K, Hyatt R E
J Appl Physiol (1985). 1986 Sep;61(3):1221-5. doi: 10.1152/jappl.1986.61.3.1221.
We describe a simulation of the vertical gradient of transpulmonary pressure (VGTP) using a stable foam, which is suitable for use in studies of the effect of the VGTP on excised lungs. We generated foams that produced linear hydrostatic pressure gradients (HPGs) from 0.18 to 0.44 cmH2O/cm depth, which were stable over time and were reproducible. The HPG was similar under static and dynamic conditions. The foam did not affect lung elastic properties or cause histological changes. We conclude that these stable foams provide a practical, inexpensive simulation of the VGTP and should be useful in studying the effects of the VGTP on regional lung behavior.
我们描述了一种使用稳定泡沫模拟跨肺压垂直梯度（VGTP）的方法，该方法适用于研究VGTP对离体肺的影响。我们制备的泡沫能产生0.18至0.44 cmH2O/cm深度的线性静水压力梯度（HPG），这些梯度随时间稳定且可重复。静态和动态条件下的HPG相似。该泡沫不影响肺的弹性特性，也不会引起组织学变化。我们得出结论，这些稳定的泡沫为VGTP提供了一种实用、廉价的模拟方法，应有助于研究VGTP对肺局部行为的影响。
