神经病理性瘙痒和神经源性瘙痒的新观点。
Emerging concepts in neuropathic and neurogenic itch.
机构信息
Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York; Mark Lebwohl Center for Neuroinflammation & Sensation, Icahn School of Medicine at Mount Sinai, New York, New York; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
出版信息
Ann Allergy Asthma Immunol. 2023 Nov;131(5):561-566. doi: 10.1016/j.anai.2023.08.008. Epub 2023 Aug 18.
Chronic pruritus has multiple etiologies, ranging from inflammatory to metabolic and neuropathic processes. However, recent advances in itch biology have shed light on potential mechanisms that explain the molecular and cellular basis of these pathologies. Furthermore, new understanding of neuroimmune itch circuits necessitates clarification of terminologies such as "neuropathic" and "neurogenic." This review provides an overview of ways new concepts may better explain the pathophysiology of a variety of chronic pruritic disorders and the rationale for directing emerging novel therapeutic strategies toward them.
慢性瘙痒有多种病因，包括炎症、代谢和神经病理性过程。然而，瘙痒生物学的最新进展揭示了潜在的机制，这些机制解释了这些病理的分子和细胞基础。此外，对神经免疫瘙痒回路的新认识需要澄清诸如“神经病理性”和“神经源性”等术语。这篇综述概述了新的概念如何更好地解释各种慢性瘙痒性疾病的病理生理学，并为针对这些疾病的新兴新型治疗策略提供了理论依据。
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