Doctoral Program in Physical Education, Health and Sport Science, Degree Programs in Comprehensive Human Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8574, Japan.
Institute of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8574, Japan.
Exp Gerontol. 2023 Oct 1;181:112278. doi: 10.1016/j.exger.2023.112278. Epub 2023 Aug 19.
This study aimed to investigate the association between whole-body (WB), arm, and leg extracellular-to-intracellular water resistance (Recw/Ricw) ratios and various physical functions of each segment and muscle mass using segmental multifrequency bioelectrical impedance analysis.
In total, 988 community-dwelling older adults were included in the analysis. Physical function was assessed using hand grip, 5-repetition sit-to-stand, 5-m habitual walk, Timed Up and Go, and single-leg balance with eyes open tests. Each segmental Recw/Ricw ratio and muscle mass were assessed at 5 and 250 kHz resistances using a segmental multifrequency bioelectrical impedance analysis device. Pearson's correlation between the segmental Recw/Ricw ratio and muscle mass and physical function was calculated, and the difference in correlation coefficients was tested using Bonferroni correction. Multiple linear regression analysis was conducted using physical function as the dependent variable and the segmental Recw/Ricw ratio as the independent variable, adjusting for sex, age, body mass index, and segmental muscle mass.
WB and leg Recw/Ricw ratios were significantly positively correlated with good hand grip performance, gait speed, mobility, balance, and standing power (p < 0.05), after adjusting for sex, age, body mass index, and muscle mass. Furthermore, the leg Recw/Ricw ratio was positively associated with lower extremity physical function compared with WB and arm Recw/Ricw ratios and muscle mass (p < 0.01). Conversely, WB muscle mass was more strongly related to grip strength than WB, arm, and leg Recw/Ricw ratios (p < 0.01).
The Recw/Ricw ratio is useful for identifying older adults with worse physical function. The Recw/Ricw ratio allows for easy and timely screening of older adults with worse physical function in clinical settings.
本研究旨在使用节段多频生物电阻抗分析探讨全身（WB）、手臂和腿部细胞外-细胞内水阻力（Recw/Ricw）比值与各节段和肌肉质量的各种身体功能之间的关系。
共纳入 988 名社区居住的老年人进行分析。使用握力、5 次重复坐立站起、5 米习惯性步行、计时起立行走和单腿睁眼平衡测试评估身体功能。使用节段多频生物电阻抗分析设备，在 5 和 250 kHz 电阻下评估每个节段的 Recw/Ricw 比值和肌肉质量。计算节段 Recw/Ricw 比值与肌肉质量和身体功能之间的 Pearson 相关系数，并使用 Bonferroni 校正检验相关系数的差异。使用物理功能作为因变量，节段 Recw/Ricw 比值作为自变量，进行多元线性回归分析，调整性别、年龄、体重指数和节段肌肉质量。
调整性别、年龄、体重指数和肌肉质量后，WB 和腿部 Recw/Ricw 比值与良好的握力表现、步态速度、移动能力、平衡和站立力量呈显著正相关（p<0.05）。此外，与 WB 和手臂 Recw/Ricw 比值和肌肉质量相比，腿部 Recw/Ricw 比值与下肢身体功能呈正相关（p<0.01）。相反，WB 肌肉质量与握力的关系强于 WB、手臂和腿部 Recw/Ricw 比值（p<0.01）。
Recw/Ricw 比值有助于识别身体功能较差的老年人。Recw/Ricw 比值可用于在临床环境中轻松且及时地筛选身体功能较差的老年人。
