Feng Qiuyang, Li Yu, Liu Cheng, Wang Xueyang, Tang Shuang, Tie Bijie, Li Xianrui, Qiu Jiang
Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; Center for Studies of Education and Psychology of Ethnic Minorities In Southwest China, Southwest University (SWU), Chongqing 400715, China.
Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; Faculty of Education, Southwest University (SWU), Chongqing 400715, China.
J Affect Disord. 2023 Nov 1;340:828-834. doi: 10.1016/j.jad.2023.08.079. Epub 2023 Aug 18.
Passive coping style (CS) and perceived stress play significant roles as influencing factors in the development of anxiety. However, the underlying neurobiological mechanism linking passive CS and perceived stress to anxiety susceptibility remains elusive. Thus, we aimed to investigate the relationships among passive CS, brain functional connectivity, perceived stress, and anxiety in young adults.
Data from the longitudinal Gene-Brain-Behavior Project(GBB) and Southwest University Longitudinal Imaging Multimodal Project(SLIM) were used. We confirmed the relationship among anxiety, passive CS and perceived stress. Then, we investigated the mediated functional connectivity between passive CS and perceived stress, and used these functional connections to predict present anxiety and follow-up anxiety one year later.
Anxiety scores were significantly positively correlated with passive CS and perceived stress. At the brain network level, connections within the default mode network (DMN) and between the somatomotor network (SMN) and subcortical network (SUN) mediated the relationship between passive CS and perceived stress. Furthermore, present anxiety and follow-up anxiety one year later could be predicted by these mediated functional connections. Nodes with greater predictive contribution were mainly located in the left anterior cingulate gyrus (ACC), left inferior parietal gyrus (IPG), right superior frontal gyrus (SFG), and left middle frontal gyrus (MFG), mainly distributed on the DMN.
These findings demonstrated that the mediated neurobiological mechanisms between passive CS and perceived stress could be used to predict present and future anxiety, which enhance understanding of the neurobiological basis of anxiety susceptibility in this passive CS and perceived stress and may have implications for early preventing and intervening mental disorders.
消极应对方式和感知到的压力作为影响因素在焦虑症的发展中起着重要作用。然而，将消极应对方式和感知到的压力与焦虑易感性联系起来的潜在神经生物学机制仍不清楚。因此，我们旨在研究年轻人中消极应对方式、脑功能连接、感知到的压力和焦虑之间的关系。
使用了来自纵向基因-脑-行为项目（GBB）和西南大学纵向成像多模态项目（SLIM）的数据。我们证实了焦虑、消极应对方式和感知到的压力之间的关系。然后，我们研究了消极应对方式和感知到的压力之间的中介功能连接，并使用这些功能连接来预测当前的焦虑以及一年后的随访焦虑。
焦虑得分与消极应对方式和感知到的压力显著正相关。在脑网络水平上，默认模式网络（DMN）内以及躯体运动网络（SMN）与皮质下网络（SUN）之间的连接介导了消极应对方式和感知到的压力之间的关系。此外，这些中介功能连接可以预测当前的焦虑以及一年后的随访焦虑。具有更大预测贡献的节点主要位于左侧前扣带回（ACC）、左侧顶下小叶（IPG）、右侧额上回（SFG）和左侧额中回（MFG），主要分布在DMN上。
这些发现表明，消极应对方式和感知到的压力之间的中介神经生物学机制可用于预测当前和未来的焦虑，这增强了对这种消极应对方式和感知到的压力下焦虑易感性神经生物学基础的理解，可能对早期预防和干预精神障碍有启示意义。
