Demeter S L, Cordasco E M
J Asthma. 1986;23(4):203-6. doi: 10.3109/02770908609073158.
The use of atropine has emerged over the past few years as a treatment for asthma. Scopolamine is pharmacologically similar to atropine and, as such, was used in a study of nine patients as a bronchodilator. These nine patients had diverse types of lung diseases. Two patients were intolerant to the medication and were not able to participate in the study. The other seven patients had variable responses with significant improvement in baseline pulmonary function testing occurring in four patients. Five of the seven patients had symptomatic relief and are now employing transdermal scopolamine on a once-every-3-days basis for the treatment of their bronchoconstriction. Baseline testing was performed to indicate response to parasympatholytic medications. Transdermal scopolamine appears to be a safe and effective means of achieving bronchodilation in some patients with asthma.
在过去几年中，阿托品已成为一种治疗哮喘的药物。东莨菪碱在药理学上与阿托品相似，因此在一项针对9名患者的研究中被用作支气管扩张剂。这9名患者患有多种类型的肺部疾病。两名患者对该药物不耐受，无法参与研究。其他7名患者有不同的反应，4名患者的基线肺功能测试有显著改善。7名患者中有5名有症状缓解，目前正在每3天使用一次透皮东莨菪碱来治疗他们的支气管收缩。进行基线测试以表明对副交感神经阻滞剂的反应。透皮东莨菪碱似乎是在一些哮喘患者中实现支气管扩张的一种安全有效的方法。
