Ren Faliang, Bressler Lindsey, Pruitt Laura, Wang Hua, Liu Li, Elston Dirk M
Department of Dermatology, Children's Hospital of Chongqing Medical University, Chongqing, China; Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Dermatology & Dermatological Surgery, Medical University of South Carolina, Charleston, South Carolina.
J Am Acad Dermatol. 2023 Dec;89(6):1238-1244. doi: 10.1016/j.jaad.2023.06.062. Epub 2023 Aug 19.
Patients with midline cutaneous anomalies of the craniospinal axis can be indicative of underlying embryonic defects, such as neural tube defects. Lack of familiarity with these midline aberrant skin findings may lead to misdiagnosis and delayed treatment. In this review, midline cutaneous anomalies of the craniospinal axis including aplasia cutis congenita, cranial and spinal dysraphism, and other developmental anomalies are explored in detail with emphasis on cutaneous clues to the diagnosis and appropriate workup.
患有颅脊柱轴中线皮肤异常的患者可能提示存在潜在的胚胎缺陷，如神经管缺陷。对这些中线皮肤异常表现缺乏了解可能导致误诊和治疗延误。在本综述中，将详细探讨颅脊柱轴中线皮肤异常，包括先天性皮肤发育不全、颅骨和脊柱神经管闭合不全以及其他发育异常，重点关注诊断的皮肤线索和适当的检查方法。
