小儿急性肾损伤的亚表型

Subphenotypes of Pediatric Acute Kidney Injury.

作者信息

Menon Shina, Gist Katja M

机构信息

Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, USA.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

出版信息

Nephron. 2023;147(12):743-746. doi: 10.1159/000531914. Epub 2023 Aug 23.

DOI:10.1159/000531914

PMID:37598663

Abstract

Acute kidney injury (AKI) is seen frequently in hospitalized patients and is associated with increased risk of mortality and adverse short- and long-term renal and systemic complications. Emerging data suggest that AKI is a heterogenous syndrome with a variety of underlying causes, predisposing illnesses, and range of clinical trajectories and outcomes. This mini-review aims to discuss emerging AKI subphenotype classifications as our understanding of the heterogeneity and underlying pathophysiology has improved.

摘要

急性肾损伤（AKI）在住院患者中很常见，并且与死亡率增加以及短期和长期肾脏及全身并发症风险升高相关。新出现的数据表明，AKI是一种异质性综合征，有多种潜在病因、易感疾病以及不同的临床病程和结局。随着我们对异质性和潜在病理生理学的理解有所提高，本综述旨在讨论急性肾损伤新出现的亚表型分类。