Wuxi Mental Health Center, Nanjing Medical University, Wuxi, Jiangsu, China.
Wuxi Mental Health Center, Nanjing Medical University, Wuxi, Jiangsu, China.
J Affect Disord. 2023 Nov 1;340:607-615. doi: 10.1016/j.jad.2023.08.098. Epub 2023 Aug 18.
To explore the causal relationship between dietary habits and five major mental disorders using the two-sample Mendelian randomization (MR) analysis.
This study was based on the summary data of the genome-wide association study (GWAS) on diet and five major mental disorders in the European population. The genetic locus data of five major mental disorders (mania, bipolar disorder, manic depression, depression, schizophrenia) from those who never eat eggs, dairy, wheat, and sugar were used. Two-sample MR analysis was conducted to evaluate the causal relationship between diet and five major mental disorders.
This study revealed a causal relationship between "Never eat Wheat products" and all five types of mental disorders (mania, bipolar disorder, manic depression, depression, schizophrenia), demonstrating a significant negative correlation (P < 0.05). However, no significant causal relationship was observed between "Never eat Sugar or foods/drinks containing sugar" and any of the five mental disorders (P > 0.05). Furthermore, the study found that the statement "Never eat eggs, dairy, wheat, sugar: I eat all of the above" had a causal relationship with mania, bipolar disorder, and manic depression, showing a significant positive correlation (P < 0.05). However, this statement did not exhibit a significant causal relationship with depression and schizophrenia (P > 0.05).
There was a negative correlation between never eating wheat products and the five mental disorders (mania, bipolar disorder, manic depression, depression, schizophrenia), indicating that never eating wheat products may reduce the risk of mental disorders.
采用双样本 Mendelian 随机化（MR）分析探讨饮食习惯与五种主要精神障碍之间的因果关系。
本研究基于欧洲人群饮食与五种主要精神障碍的全基因组关联研究（GWAS）的汇总数据。使用从不食用鸡蛋、奶制品、小麦和糖的人群中五种主要精神障碍（躁狂症、双相情感障碍、躁郁症、抑郁症、精神分裂症）的遗传基因座数据进行双样本 MR 分析，以评估饮食与五种主要精神障碍之间的因果关系。
本研究揭示了“从不食用小麦制品”与所有五种精神障碍（躁狂症、双相情感障碍、躁郁症、抑郁症、精神分裂症）之间存在因果关系，表现出显著的负相关（P<0.05）。然而，“从不食用糖或含糖食物/饮料”与五种精神障碍中的任何一种都没有观察到显著的因果关系（P>0.05）。此外，研究发现“从不食用鸡蛋、奶制品、小麦、糖：我食用以上所有食物”与躁狂症、双相情感障碍和躁郁症具有因果关系，表现出显著的正相关（P<0.05）。然而，这种说法与抑郁症和精神分裂症之间没有显著的因果关系（P>0.05）。
从不食用小麦制品与五种精神障碍（躁狂症、双相情感障碍、躁郁症、抑郁症、精神分裂症）呈负相关，表明从不食用小麦制品可能会降低精神障碍的风险。
