Zhang Qinxia, Zhang Haifu, Xu Qinxing
Department of Respiratory Medicine, The First People's Hospital of Fuyang, Hangzhou, Zhejiang, 311400, People's Republic of China.
Department of Medicine, The First People's Hospital of Fuyang, Hangzhou, Zhejiang, 311400, People's Republic of China.
Int J Chron Obstruct Pulmon Dis. 2024 Feb 1;19:343-351. doi: 10.2147/COPD.S442725. eCollection 2024.
Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disorder often accompanied by comorbidities. Although the past few years have witnessed significant scientific progress, the potential relationship between COPD and mental illness remains a subject of debate.
We retrieved COPD data from the genome-wide association studies (GWAS) directory and data on mental illnesses, including Alzheimer's disease, schizophrenia, panic disorder, attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder, multiple disabilities, obsessive-compulsive disorder, post-traumatic stress disorder, and schizophrenia, from the Psychiatric Genomics Consortium. A two-sample Mendelian randomization (MR) approach was applied to explore the association between COPD and mental illnesses, with subgroup analyses based on smoking history.
Our two-sample MR analysis revealed no causal link between overall COPD and the development of common psychiatric disorders. Subgroup analyses based on smoking history showed no causal association between never-smokers with COPD and the occurrence of psychiatric disorders. However, ever-smokers with COPD were associated with a significantly increased risk of ADHD (OR: 2.303, 95% CI: 1.558-3.403, P = 0.001) and a modestly reduced risk of Alzheimer's disease (OR: 0.994, 95% CI: 0.988-0.999, P = 0.034).
COPD patients with a history of smoking face a higher risk of developing ADHD but may experience a slight reduction in the risk of Alzheimer's disease. Conversely, there was no observed causal association between COPD and psychiatric disorders among patients who never smoked.
慢性阻塞性肺疾病（COPD）是一种常见的呼吸系统疾病，常伴有合并症。尽管在过去几年里取得了重大的科学进展，但COPD与精神疾病之间的潜在关系仍是一个有争议的话题。
我们从全基因组关联研究（GWAS）目录中检索了COPD数据，并从精神基因组学联盟获取了包括阿尔茨海默病、精神分裂症、惊恐障碍、注意力缺陷多动障碍（ADHD）、双相情感障碍、重度抑郁症、多重残疾、强迫症、创伤后应激障碍和精神分裂症等精神疾病的数据。采用两样本孟德尔随机化（MR）方法探讨COPD与精神疾病之间的关联，并根据吸烟史进行亚组分析。
我们的两样本MR分析显示，总体COPD与常见精神障碍的发生之间没有因果关系。基于吸烟史的亚组分析表明，从不吸烟的COPD患者与精神障碍的发生之间没有因果关联。然而，曾经吸烟的COPD患者患ADHD的风险显著增加（比值比：2.303，95%置信区间：1.558 - 3.403，P = 0.001），患阿尔茨海默病的风险略有降低（比值比：0.994，95%置信区间：0.988 - 0.999，P = 0.034）。
有吸烟史的COPD患者患ADHD的风险更高，但患阿尔茨海默病的风险可能略有降低。相反，从不吸烟的患者中未观察到COPD与精神障碍之间存在因果关联。
