Department of Microbiology & Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143, USA.
Department of Microbiology & Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143, USA.
Trends Immunol. 2023 Oct;44(10):792-806. doi: 10.1016/j.it.2023.07.006. Epub 2023 Aug 18.
RNA is integral to the regulatory circuits that control cell identity and behavior. Cis-regulatory elements in mRNAs interact with RNA-binding proteins (RBPs) that can alter RNA sequence, stability, and translation into protein. Similarly, long noncoding RNAs (lncRNAs) scaffold ribonucleoprotein complexes that mediate transcriptional and post-transcriptional regulation of gene expression. Indeed, cell programming is fundamental to multicellular life and, in this era of cellular therapies, it is of particular interest in T cells. Here, we review key concepts and recent advances in our understanding of the RNA circuits and RBPs that govern mammalian T cell differentiation and immune function.
RNA 是调控细胞身份和行为的调控回路的重要组成部分。mRNA 中的顺式调控元件与 RNA 结合蛋白 (RBP) 相互作用，RBP 可以改变 RNA 的序列、稳定性和翻译为蛋白质。同样，长非编码 RNA (lncRNA) 支架核糖核蛋白复合物，介导基因表达的转录和转录后调控。事实上，细胞编程是多细胞生命的基础，在细胞治疗的时代，它在 T 细胞中尤其受到关注。在这里，我们回顾了 RNA 回路和 RBP 调控哺乳动物 T 细胞分化和免疫功能的关键概念和最新进展。
