使用一种共同配体揭示多巴胺受体的分歧。
Dopamine receptor divergence revealed using a common ligand.
机构信息
Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA.
Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA.
出版信息
Trends Pharmacol Sci. 2023 Oct;44(10):637-639. doi: 10.1016/j.tips.2023.08.002. Epub 2023 Aug 19.
Abstract
Rational drug design for G protein-coupled receptors (GPCRs) remains a challenging area. A new study from the Xu, Roth, and Zhang groups provides a complete set of active structures for the entire dopamine receptor family bound with rotigotine that will aid in designing selective agonists for these important therapeutic targets.
摘要
针对 G 蛋白偶联受体（GPCRs）的合理药物设计仍然是一个具有挑战性的领域。来自 Xu、Roth 和 Zhang 小组的一项新研究提供了整套与罗替高汀结合的多巴胺受体家族的活性结构，这将有助于为这些重要的治疗靶点设计选择性激动剂。
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本文引用的文献
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