通过受贻贝启发的粘合剂增强磷酸钙骨水泥的力学性能作为骨替代物：它们相互作用的要点

Enhanced mechanic properties of calcium phosphate cements via mussel-inspired adhesive as bone substitute: Highlights of their interactions.

作者信息

Yuan Rupan, Zhou Sijie, Xiong Xiong, Yang Dan, Lin Donghu, Li Taiyi, He Bin, Wei Guihua, Qu Shuxin

机构信息

Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China.

School of Life Science and Engineering, Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, Southwest Jiaotong University, Chengdu, China.

出版信息

Biomed Mater Eng. 2024;35(1):13-26. doi: 10.3233/BME-230017.

DOI:10.3233/BME-230017

PMID:37599515

Abstract

BACKGROUND

Inspired by natural bones, many organic components were added to Calcium Phosphate Cements (CPCs) to improve their mechanical strength. However, the strength of these composite CPCs is limited by the low strength of organic components itself and the weak interaction between organic components and CPCs.

OBJECTIVE

Firstly, a composite CPC containing mussel-inspired adhesive, Poly-(Dopamine Methacrylamide-co-2-methoxy Ethylacrylate) (pDM) was developed. Secondly, the interactions between pDM and CPC and their effect on mechanical properties were investigated.

METHODS

The interactions between pDM and CPC were performed by Nuclear Magnetic Resonance, Laser Raman, X-ray Photoelectron Spectroscopy, Fourier Transform-Infrared Spectroscopy and X-ray Diffraction Analysis.

RESULTS

The toughness and compressive strength of pDM-CPC scaffold were both significantly enhanced, because of the enhanced interface binding strength among CPC and pDM due to their interaction and the improved mechanical strength of pDM owing to its self-oxidation cross-linking. The toughness of pDM-CPC scaffolds increased with the increased contents of pDM, while pDM-CPC scaffold containing 35 wt.% pDM had the highest compressive strength of all, which the latter was more than five times compared to that of CPC.

CONCLUSION

The mechanically strong pDM-CPC scaffolds has potential application in bone regeneration as well as in craniofacial and orthopedic repair.

摘要

背景

受天然骨骼启发，许多有机成分被添加到磷酸钙骨水泥（CPCs）中以提高其机械强度。然而，这些复合磷酸钙骨水泥的强度受到有机成分本身强度较低以及有机成分与磷酸钙骨水泥之间弱相互作用的限制。

目的

首先，制备一种含有受贻贝启发的粘合剂聚（多巴胺甲基丙烯酰胺-co-2-甲氧基丙烯酸乙酯）（pDM）的复合磷酸钙骨水泥。其次，研究pDM与磷酸钙骨水泥之间的相互作用及其对机械性能的影响。

方法

通过核磁共振、激光拉曼光谱、X射线光电子能谱、傅里叶变换红外光谱和X射线衍射分析来研究pDM与磷酸钙骨水泥之间的相互作用。

结果

pDM-CPC支架的韧性和抗压强度均显著提高，这是由于pDM与磷酸钙骨水泥之间的相互作用增强了它们之间的界面结合强度，以及pDM通过自身氧化交联提高了机械强度。pDM-CPC支架的韧性随着pDM含量的增加而增加，而含有35 wt.% pDM的pDM-CPC支架具有最高的抗压强度，后者是磷酸钙骨水泥抗压强度的五倍多。