Sebastião Cruz S, Sacomboio Euclides, Francisco Ngiambudulu M, Cassinela Edson K, Mateus António, David Zinga, Pimentel Victor, Paixão Joana, Neto de Vasconcelos Jocelyne, Morais Joana
Instituto Nacional de Investigação em Saúde (INIS) Luanda Angola.
Centro de Investigação em Saúde de Angola (CISA) Caxito Angola.
Health Sci Rep. 2023 Aug 16;6(8):e1498. doi: 10.1002/hsr2.1498. eCollection 2023 Aug.
SARS-CoV-2 infection is a public health concern. Several aspects related to the pattern of infection remain unclear. This study aimed to investigate the blood pressure pattern among blood donors exposed to SARS-CoV-2 in Luanda, Angola, a sub-Saharan African country.
We performed a retrospective analysis containing 343 blood donors from December 2019 to September 2020. Parametric tests compared means while and logistic regression checked features associated with high blood pressure and were considered significant when < 0.05.
The mean age of blood donors was 32.2 ± 8.81 years (ranging from 18 to 61 years) and 93% of the men's gender. Overall, 4.7% of the studied population had been exposed to SARS-CoV-2. High blood pressure prevalence increased from unexposed to exposed SARS-CoV-2 (6.7%-18.8%, = 0.071). SARS-CoV-2 exposure increase systole (131 ± 12.2 mmHg to 136 ± 14.2 mmHg, = 0.098), diastole (79.9 ± 9.53 mmHg to 84.2 ± 12.7 mmHg, = 0.086), pulse in beats per minute (72.0 ± 11.1 to 73.7 ± 8.50, = 0.553), and decrease donating time (6.31 ± 3.72 min to 5.48 ± 1.61 min, = 0.371). Chances of having high blood pressure were high [OR: 3.20 (95% confidence interval [CI]: 0.85-12.1), = 0.086] in exposed SARS-CoV-2. Donors exposed to SARS-CoV-2 with abnormal donation time increased from the donor up to 40 years to over 40 years (from 35.7% to 50%, = 0.696). The mean systolic, diastolic, and pulse pressure were higher for non-O donors ( > 0.05). A significant link was observed, between the Rhesus factor and blood pressure status ( = 0.032).
We showed important variations in blood pressure indices of the Angolan population exposed to SARS-CoV-2. Older age and non-O blood groups appear to be important biological factors for SARS-CoV-2 infection, as well as the risk of developing cardiovascular disease after or during SARS-CoV-2 exposure. Further studies assessing the impact on cardiovascular functions with ongoing or long-term SARS-CoV-2 exposure in individuals from resource-limited countries should be considered.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染是一个公共卫生问题。与感染模式相关的几个方面仍不清楚。本研究旨在调查在撒哈拉以南非洲国家安哥拉罗安达接触SARS-CoV-2的献血者的血压模式。
我们对2019年12月至2020年9月的343名献血者进行了回顾性分析。参数检验比较均值，卡方检验和逻辑回归检查与高血压相关的特征，当P<0.05时被认为具有统计学意义。
献血者的平均年龄为32.2±8.81岁（范围为18至61岁），男性占93%。总体而言，4.7%的研究人群接触过SARS-CoV-2。从未接触SARS-CoV-2到接触SARS-CoV-2，高血压患病率有所增加（6.7%-18.8%，P=0.071）。接触SARS-CoV-2使收缩压升高（从131±12.2mmHg升至136±14.2mmHg，P=0.098），舒张压升高（从79.9±9.53mmHg升至84.2±12.7mmHg，P=0.086），每分钟脉搏数增加（从72.0±11.1升至73.7±8.50，P=0.553），献血时间缩短（从6.31±3.72分钟降至5.48±1.61分钟，P=0.371）。接触SARS-CoV-2的人群患高血压的几率较高[比值比：3.20（95%置信区间[CI]：0.85-12.1），P=0.086]。接触SARS-CoV-2且献血时间异常的献血者中，40岁及以下的比例从35.7%增至40岁以上的50%（P=0.696）。非O型献血者的平均收缩压、舒张压和脉压更高（P>0.05）。观察到恒河猴因子与血压状态之间存在显著关联（P=0.032）。
我们发现接触SARS-CoV-2的安哥拉人群的血压指标存在重要差异。年龄较大和非O血型似乎是SARS-CoV-2感染的重要生物学因素，以及在接触SARS-CoV-2之后或期间发生心血管疾病的风险因素。应考虑进一步开展研究，评估资源有限国家的个体持续或长期接触SARS-CoV-2对心血管功能的影响。
