Mullins Jeannette, Al-Tarbsheh Ali Hani, Chieng Hau, Chaukiyal Pooja, Ghalib Sana, Jain Esha, Dawani Om, Santelises Robledo Fabiana Maria, Chong Woon H, Feustel Paul J, Subik Kristina, Chopra Amit
Department of Medicine, Albany Medical Center 43 New Scotland Avenue, Albany, New York, USA.
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Albany Medical Center 16 New Scotland Avenue, Albany, New York, USA.
Am J Blood Res. 2021 Feb 15;11(1):53-58. eCollection 2021.
There is conflicting data in the literature about the association of ABO blood type and susceptibility to COVID-19 infection. Moreover, very few studies have examined the effect of blood type on severity of COVID-19 infection.
This was a retrospective, single-center analysis of adult patients with COVID-19 infection who were hospitalized between March 8 to July 31, 2020 at a regional tertiary care hospital. All patients who were hospitalized with a diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection and had a documented ABO blood type were enrolled in this analysis. Aims of this study were to examine the prevalence of ABO blood types in patients with COVID-19 infection and to determine the frequency of severe COVID-19 infection among ABO blood types.
A total of 227 cases were identified. Our cohort had a mean age of 63.3 years and 60% were males. The most common blood type was O (49%) followed by A (36%), which was similar to the prevalence of ABO blood types in our regional population. Moreover, there was no significant difference in the frequency of severe COVID-19 infection between ABO blood types (O: 50%, A: 53%, B: 56%, AB: 57%; P=0.93), or any additional outcomes including in-hospital mortality rate (P=0.72), need for ICU admission (P=0.66), ICU free days at day 28 (P=0.51), hospital free days at day 28 (P=0.43), or need for acute renal replacement therapy (P=0.09).
We did not find an increased susceptibility of any blood type to COVID-19 infection, nor was there an increased risk of severe COVID-19 infection in any ABO blood types.
关于ABO血型与新冠病毒感染易感性之间的关联，文献中的数据存在冲突。此外，很少有研究探讨血型对新冠病毒感染严重程度的影响。
这是一项对2020年3月8日至7月31日期间在一家地区三级护理医院住院的成年新冠病毒感染患者进行的回顾性单中心分析。所有因严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染住院且有记录的ABO血型患者均纳入本分析。本研究的目的是检查新冠病毒感染患者中ABO血型的患病率，并确定不同ABO血型中重症新冠病毒感染的频率。
共确定了227例病例。我们的队列平均年龄为63.3岁，60%为男性。最常见的血型是O型（49%），其次是A型（36%），这与我们地区人群中ABO血型的患病率相似。此外，不同ABO血型之间重症新冠病毒感染的频率没有显著差异（O型：50%，A型：53%，B型：56%，AB型：57%；P = 0.93），在包括住院死亡率（P = 0.72）、入住重症监护病房的需求（P = 0.66）、第28天无重症监护病房天数（P = 0.51）、第28天无住院天数（P = 0.43）或急性肾替代治疗需求（P = 0.09）等任何其他结果方面也没有显著差异。
我们没有发现任何血型对新冠病毒感染的易感性增加，也没有发现任何ABO血型中重症新冠病毒感染的风险增加。
