College of Basic Medical Science, China Three Gorges University, Yichang, China.
Institute of Infection and Inflammation, China Three Gorges University, Yichang, China.
Front Endocrinol (Lausanne). 2023 Aug 3;14:1202463. doi: 10.3389/fendo.2023.1202463. eCollection 2023.
Neutrophil extracellular traps (NETs) are known as extracellular fibers networks consisting of antimicrobial proteins and decondensated chromatin DNA released by activated neutrophils. NETosis is a NETs-induced neutrophilic cell death which is unique from necrosis or apoptosis. Besides its neutralizing pathogen, NETosis plays a crucial role in diabetes and diabetes-related complications. In patients with diabetes, NETs-releasing products are significantly elevated in blood, and these findings confirm the association of NETosis and diabetic complications, including diabetic wound healing, diabetic retinopathy, and atherosclerosis. This article briefly summarizes the mechanisms of NETosis and discusses its contribution to the pathogenesis of diabetes-related complications and suggests new therapeutic targets by some small molecule compounds.
中性粒细胞胞外诱捕网（NETs）是由激活的中性粒细胞释放的抗微生物蛋白和去凝聚染色质 DNA 组成的细胞外纤维网络。NETosis 是一种 NETs 诱导的中性粒细胞死亡，与坏死或凋亡不同。除了中和病原体外，NETosis 在糖尿病及其相关并发症中起着至关重要的作用。在糖尿病患者中，血液中释放 NETs 的产物显著升高，这些发现证实了 NETosis 与糖尿病并发症之间的关联，包括糖尿病伤口愈合、糖尿病视网膜病变和动脉粥样硬化。本文简要总结了 NETosis 的机制，并讨论了其对糖尿病相关并发症发病机制的贡献，并提出了一些小分子化合物作为新的治疗靶点。
