Wei Yongjun, Xiao Ping, Wu Benjuan, Chen Fuxi, Shi Xiaofeng
Department of Emergency, Tianjin First Central Hospital, Tianjin, 300192, China.
Department of Emergency, Tianjin Beichen Hospital, Tianjin, 300400, China.
Open Life Sci. 2023 Aug 17;18(1):20220639. doi: 10.1515/biol-2022-0639. eCollection 2023.
The diagnosis of sepsis still lacks a practical and reliable gold standard. The purpose of this study was to confirm the effect of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) combined with soluble suppression of tumorigenicity 2 (sST2) in the diagnosis of sepsis through the correlation between sTREM-1, sST2, and sequential organ failure assessment (SOFA) scores. Baseline data of 91 patients with sepsis in the intensive care unit were collected, sTREM-1 and sST2 were detected, and the correlation between markers and SOFA score was analyzed. Besides, the prognostic value of baseline and postadmission indicators for sepsis was analyzed with death as the outcome. The results showed that the expressions of sST2 and sTREM-1 in death group and survival group were higher than those in the survival group ( < 0.05). Correlation analysis showed that sST2, sTREM-1, and the joint diagnosis model had a high correlation with SOFA score ( < 0.05), but poor correlation with Acute Physiology and Chronic Health Evaluation Ⅱ score ( > 0.05). Among them, joint diagnosis model has the highest correlation. Receiver operating characteristic curve analysis showed that combined diagnosis had higher area under curve values. sTREM-1/sST2 can be better used in the diagnosis of sepsis than the single biomarker detection, and the combination of the above two biomarkers has potential application value in the detection and prognosis prediction of sepsis.
脓毒症的诊断仍缺乏实用且可靠的金标准。本研究的目的是通过髓系细胞触发受体-1（sTREM-1）、可溶性肿瘤抑制因子2（sST2）与序贯器官衰竭评估（SOFA）评分之间的相关性，来证实sTREM-1联合sST2在脓毒症诊断中的作用。收集了重症监护病房91例脓毒症患者的基线数据，检测sTREM-1和sST2，并分析标志物与SOFA评分之间的相关性。此外，以死亡为结局，分析脓毒症基线和入院后指标的预后价值。结果显示，死亡组和存活组中sST2和sTREM-1的表达均高于存活组（<0.05）。相关性分析表明，sST2、sTREM-1及联合诊断模型与SOFA评分具有高度相关性（<0.05），但与急性生理与慢性健康状况评分Ⅱ相关性较差（>0.05）。其中，联合诊断模型的相关性最高。受试者工作特征曲线分析表明，联合诊断的曲线下面积值更高。与单一生物标志物检测相比，sTREM-1/sST2能更好地用于脓毒症的诊断，上述两种生物标志物的联合在脓毒症的检测和预后预测中具有潜在应用价值。
