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活性氧诱导的脂质过氧化及其在铁死亡中的作用。

ROS induced lipid peroxidation and their role in ferroptosis.

作者信息

Endale Hiwot Tezera, Tesfaye Winta, Mengstie Tiget Ayelgn

机构信息

Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Department of Human Physiology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

出版信息

Front Cell Dev Biol. 2023 Aug 1;11:1226044. doi: 10.3389/fcell.2023.1226044. eCollection 2023.

DOI:10.3389/fcell.2023.1226044
PMID:37601095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10434548/
Abstract

Reactive oxygen species (ROS) play a crucial part in the process of cell death, including apoptosis, autophagy, and ferroptosis. ROS involves in the oxidation of lipids and generate 4-hydroxynonenal and other compounds associated with it. Ferroptosis may be facilitated by lipid peroxidation of phospholipid bilayers. In order to offer novel ideas and directions for the investigation of disorders connected to these processes, we evaluate the function of ROS in lipid peroxidation which ultimately leads to ferroptosis as well as proposed crosstalk mechanisms between ferroptosis and other types programmed cell death.

摘要

活性氧（ROS）在细胞死亡过程中起着关键作用，包括细胞凋亡、自噬和铁死亡。ROS参与脂质氧化并生成4-羟基壬烯醛及与之相关的其他化合物。磷脂双层的脂质过氧化可能会促进铁死亡。为了为与这些过程相关的疾病研究提供新思路和方向，我们评估了ROS在最终导致铁死亡的脂质过氧化中的作用，以及提出的铁死亡与其他类型程序性细胞死亡之间的相互作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e1/10434548/0ea12de90fe3/fcell-11-1226044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e1/10434548/0ea12de90fe3/fcell-11-1226044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e1/10434548/0ea12de90fe3/fcell-11-1226044-g001.jpg

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ROS induced lipid peroxidation and their role in ferroptosis.

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[2]
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[3]
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[4]
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[6]
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[10]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Polysaccharides as antioxidants and prooxidants in managing the double-edged sword of reactive oxygen species.

Biomed Pharmacother. 2023-3

[2]
Induction mechanism of ferroptosis: A novel therapeutic target in lung disease.

Front Pharmacol. 2022-12-9

[3]
Role of ferroptosis on tumor progression and immunotherapy.

Cell Death Discov. 2022-10-26

[4]
Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress.

Redox Biol. 2022-11

[5]
Mitochondrial event as an ultimate step in ferroptosis.

Cell Death Discov. 2022-10-8

[6]
Identification of as a biomarker and contributor of ferroptosis in clear cell renal cell carcinoma.

Transl Cancer Res. 2022-8

[7]
Patulin disrupts SLC7A11-cystine-cysteine-GSH antioxidant system and promotes renal cell ferroptosis both in vitro and in vivo.

Food Chem Toxicol. 2022-8

[8]
Ferroptosis at the intersection of lipid metabolism and cellular signaling.

Mol Cell. 2022-6-16

[9]
Mitochondria and ferroptosis.

Curr Opin Physiol. 2022-2

[10]
GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis.

Ecotoxicol Environ Saf. 2022-4-1

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