State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang 330047, China.
Department of Critical Care Medicine, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
Biomed Pharmacother. 2023 Mar;159:114221. doi: 10.1016/j.biopha.2023.114221. Epub 2023 Jan 10.
Polysaccharides, a class of naturally occurring carbohydrates, were widely presented in animals, plants, and microorganisms. Recently, health benefits of polysaccharides have attracted much attention due to their unique characteristics in reactive oxygen species (ROS) management. ROS, by-products of aerobic metabolism linked to food consumption, exhibited a dual role in protecting cells and fostering pathogenesis collectively termed double-edged sword. Some interesting studies reported that polysaccharides could behave as prooxidants under certain conditions, besides antioxidant capacities. Potentiation of the bright side of ROS could contribute to the host defense that was vitally important for the polysaccharides acting as biological response modifiers. Correspondingly, disease prevention of polysaccharides linked to the management of ROS production was systematically described and discussed in this review. Furthermore, major challenges and future prospects were presented, aiming to provide new insight into applying polysaccharides as functional food ingredients and medicine.
多糖是一类天然存在的碳水化合物，广泛存在于动物、植物和微生物中。由于其在活性氧（ROS）管理方面的独特特性，多糖的健康益处最近引起了广泛关注。ROS 是与食物消费有关的需氧代谢的副产物，在保护细胞和促进发病机制方面发挥着双重作用，通常被称为双刃剑。一些有趣的研究报告称，多糖在某些条件下可以表现为氧化剂，除了抗氧化能力之外。增强 ROS 的光明面可能有助于宿主防御，这对于多糖作为生物反应调节剂的作用至关重要。相应地，本综述系统地描述和讨论了与 ROS 产生管理相关的多糖的疾病预防作用。此外，还提出了主要挑战和未来展望，旨在为将多糖作为功能性食品成分和药物应用提供新的见解。
