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墨西哥免疫规划粗覆盖率的比较估计:一项全国性调查的结果

Comparative estimates of crude coverage of the Mexican immunization program: Findings from a national survey.

作者信息

Angélica López-Hernández, Carlos Castillo-Salgado, Julia Berenice Ramírez-González, Silvia Martínez Valverde, Ramon Durazo-Arvizu, Luis Duran-Arenas, Reyna Lizette Pacheco-Domínguez

机构信息

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

出版信息

Vaccine X. 2023 Aug 3;15:100364. doi: 10.1016/j.jvacx.2023.100364. eCollection 2023 Dec.

Abstract

The purpose of the study is to provide estimates for immunization coverage, considering single-dose and schemes (three or five vaccines), by comparing self-report method to immunization cards, while also assessing the timeliness of immunization in Mexico, with reference to Mexican Immunization Program guidelines. Data on immunization was obtained from the Mexican Immunization Survey conducted in 2017 that aimed to assess crude (card-based) coverage at the regional level. Timely immunization was defined with reference to National Immunization Program guidelines, and immunization coverage was defined as a three or five vaccine scheme, based on previous national reports of immunization coverage. Immunization coverage estimates account for sample weights from the complex survey design. We used weighted immunization coverage estimates to assess the extent to which immunization cards and self-reporting concurred. It was found that most Mexican children are not receiving their full vaccine schedule in a timely manner. Concerning children under twelve months of age, the coverage targets for National Immunization of 95 % was not reached for either vaccine, and only 2.94 % (95 % CI 0.92-9.01) who had been receiving a three-vaccine scheme were considered as fully immunized in a timely manner. In contrast, coverage increased to 33.94 % (95 % CI 26.99-41.66), when untimely immunizations were taken into account, and the 95 % target was reached for five vaccines. Likewise, there is little correlation between self-report and immunization cards but rates show more concurrence, when only considering the proportion of true positives. In conclusion it was find that children at a local level are vaccinated in an incomplete and untimely manner. In order to improve immunization systems, a nominal registry of administered doses is thus of paramount importance. There is a need to address underlying health inequalities, as well as the factors associated with these, resulting in improved chances of a disease-free childhood and healthy life.

摘要

本研究的目的是通过将自我报告法与免疫接种卡进行比较,估算单剂量和免疫方案(三种或五种疫苗)的免疫接种覆盖率,同时参照墨西哥免疫规划指南评估墨西哥免疫接种的及时性。免疫接种数据来自2017年开展的墨西哥免疫接种调查,该调查旨在评估区域层面的粗略(基于卡片)覆盖率。及时免疫接种是参照国家免疫规划指南定义的,免疫接种覆盖率根据以往国家免疫接种覆盖率报告定义为三种或五种疫苗方案。免疫接种覆盖率估算考虑了复杂调查设计中的样本权重。我们使用加权免疫接种覆盖率估算值来评估免疫接种卡与自我报告的一致程度。结果发现,大多数墨西哥儿童没有及时完成全部疫苗接种计划。对于12个月以下的儿童,两种疫苗的国家免疫接种覆盖率目标均未达到,在接受三种疫苗方案的儿童中,只有2.94%(95%置信区间0.92 - 9.01)被视为及时完全免疫接种。相比之下,若将未及时接种的情况考虑在内,覆盖率增至33.94%(95%置信区间26.99 - 41.66),五种疫苗的覆盖率达到了95%的目标。同样,自我报告与免疫接种卡之间几乎没有相关性,但仅考虑真阳性比例时,两者的比率显示出更高的一致性。总之,研究发现当地儿童的疫苗接种不完整且不及时。因此,为了改善免疫接种系统,记录接种剂量的名义登记册至关重要。有必要解决潜在的健康不平等问题以及与之相关的因素,从而增加儿童无病童年和健康生活的机会。

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