Chen Jia, Tang Gusheng, Peng Ye, Cheng Hui
Department of Hematology, Naval Military Medical University, First Affiliated Hospital, Shanghai, China.
Department of Nuclear Medicine, Naval Military Medical University, First Affiliated Hospital, Shanghai, China.
Front Oncol. 2023 Aug 3;13:1218863. doi: 10.3389/fonc.2023.1218863. eCollection 2023.
Parathyroid adenomas are benign proliferative disorders of parathyroid glands. Patients typically exhibit hyperparathyroidism and elevated serum calcium levels due to elevated levels of parathyroid hormone (PTH). We report a newly diagnosed case of a rare pathological osteolytic lesion. Radiological evaluation revealed multiple bony lesions in multiple parts of the pelvis, vertebral body, and spinous process, suggesting hematological neoplasms or bone marrow metastatic carcinoma. The morphology revealed many abnormal cells in the bone marrow smear. Furthermore, serum calcium and PTH levels were significantly increased compared to normal levels. Doppler color ultrasound showed a thyroid mass (left), suspected parathyroid adenoma, thyroid, and isthmus nodular goiter (right). The patient underwent bilateral neck exploration with parathyroidectomy, and serum calcium and PTH levels significantly decreased on the second day after surgery and had a surgical cure.
甲状旁腺腺瘤是甲状旁腺的良性增殖性疾病。由于甲状旁腺激素（PTH）水平升高，患者通常表现为甲状旁腺功能亢进和血清钙水平升高。我们报告一例新诊断的罕见病理性溶骨性病变病例。放射学评估显示骨盆、椎体和棘突多个部位有多处骨病变，提示血液系统肿瘤或骨髓转移性癌。骨髓涂片形态显示有许多异常细胞。此外，血清钙和PTH水平与正常水平相比显著升高。多普勒彩色超声显示甲状腺肿物（左侧），疑似甲状旁腺腺瘤，甲状腺及峡部结节性甲状腺肿（右侧）。患者接受了双侧颈部探查并行甲状旁腺切除术，术后第二天血清钙和PTH水平显著下降，手术治愈。
