Li Xiucai, Fang Xuee, Zhou Ligang, Mao Yanjun
Department of Endocrinology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, People's Republic of China.
Department of Tuberculosis, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai, People's Republic of China.
Int J Gen Med. 2023 Aug 14;16:3465-3472. doi: 10.2147/IJGM.S412675. eCollection 2023.
A high incidence of depression has been reported in patients with pulmonary tuberculosis and diabetes mellitus (DM-PTB). However, the association between depression and DM-PTB is poorly understood and requires further investigation. This study aimed to evaluate the prevalence of depression and the associated factors in patients with DM-PTB.
A cross-sectional study was conducted among DM-PTB patients at the Tuberculosis Department of Shanghai Pulmonary Hospital Affiliated to Tongji University, China, enrolled between June 2021 and October 2021. The depression status, nutritional status, and the quality of life of the patients were evaluated using Patient Health Questionnaire-9 (PHQ-9), Nutritional Risk Screening 2002 (NRS2002), and Quality of Life Instruments for Chronic Diseases-Pulmonary Tuberculosis (QLICD-PT), respectively.
A total number of 280 DM-PTB patients were screened, of whom 22 were excluded for missing data. Among the 258 DM-PTB patients subjected to analysis, 199 patients (77.13%) had PHQ-9 scores above 10. The patients with depression are more likely to have a lower monthly income, body mass index (BMI), and QLICD-PT than those without depression. The NRS2002 score and glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT) levels in the depression group were more likely to be higher than those in the control group. Multivariate logistic regression analysis showed that physical function [OR = 0.798, 95% confidence interval (CI), 0.716-0.889, < 0.001] was a protective factor against depression, whereas NRS2002 ≥ 3 (OR = 2.299, 95% CI, 1.095-4.825, = 0.028), GPT (OR = 1.048, 95% CI, 1.018-1.079, = 0.002), and social function (OR = 1.103, 95% CI, 1.033-1.179, = 0.004) were risk factors of depression.
Depression in DM-PTB patients may be associated with monthly income, BMI, QLICD-PT scores, NRS2002 scores, GPT, and GOT levels.
据报道，肺结核合并糖尿病患者（DM-PTB）中抑郁症的发病率较高。然而，抑郁症与DM-PTB之间的关联尚不清楚，需要进一步研究。本研究旨在评估DM-PTB患者中抑郁症的患病率及其相关因素。
对2021年6月至2021年10月在中国同济大学附属上海市肺科医院结核科登记的DM-PTB患者进行了一项横断面研究。分别使用患者健康问卷-9（PHQ-9）、营养风险筛查2002（NRS2002）和慢性病患者生活质量量表-肺结核（QLICD-PT）评估患者的抑郁状态、营养状况和生活质量。
共筛查了280例DM-PTB患者，其中22例因数据缺失被排除。在纳入分析的258例DM-PTB患者中，199例（77.13%）的PHQ-9评分高于10分。与无抑郁症的患者相比，抑郁症患者的月收入、体重指数（BMI）和QLICD-PT得分更低的可能性更大。抑郁症组的NRS2002评分、谷丙转氨酶（GPT）和谷草转氨酶（GOT）水平高于对照组的可能性更大。多因素logistic回归分析显示，身体功能[比值比（OR）=0.798，95%置信区间（CI）为0.716-0.889，P<0.001]是预防抑郁症的保护因素，而NRS2002≥3（OR=2.299，95%CI为1.095-4.825，P=0.028）、GPT（OR=1.048，95%CI为1.018-1.079，P=0.002）和社会功能（OR=1.103，95%CI为1.033-1.179，P=0.004）是抑郁症的危险因素。
DM-PTB患者的抑郁症可能与月收入、BMI、QLICD-PT评分、NRS2002评分、GPT和GOT水平有关。
