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血清D-2-羟基戊二酸及D-2HG/L-2HG比值可预测急性髓系白血病中的突变。

Serum D-2-hydroxyglutarate and the ratio of D-2HG/L-2HG predict mutation in acute myeloid leukemia.

作者信息

Zhang Chelsea, Chu Andrew, Boriack Richard, Collins Robert, Xu Jing, Oliver Dwight, Zheng Ruifang, Rakheja Dinesh, Chen Weina

机构信息

Departments of Pathology University of Texas Southwestern Medical Center Dallas Texas USA.

Children's Medical Center Dallas Dallas Texas USA.

出版信息

EJHaem. 2023 Jun 19;4(3):723-727. doi: 10.1002/jha2.723. eCollection 2023 Aug.

DOI:10.1002/jha2.723
PMID:37601838
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10435681/
Abstract

This study investigates whether serum D-2HG (D-2-hydroxyglutarate) produced by the mutated isocitrate dehydrogenase (IDH) can predict mutations in acute myeloid leukemia (AML) at diagnosis. D-2HG and L-2HG are measured by liquid chromatography-tandem mass spectrometry. D-2HG, total 2HG and the D/L ratio (D-2HG/L-2HG) are significantly higher in cases than in cases. The optimal cutoff values to predict mutations at 100% sensitivity (specificity 91%-94%) are >588 ng/mL for D-2HG and >2.33 for the D/L ratio. Our study indicates that elevated serum D-2HG and the D/L ratio may serve as noninvasive biomarkers of mutation in AML.

摘要

本研究调查了由突变的异柠檬酸脱氢酶（IDH）产生的血清D-2-羟基戊二酸（D-2HG）是否能够在急性髓系白血病（AML）诊断时预测IDH突变。采用液相色谱-串联质谱法测定D-2HG和L-2HG。病例组的D-2HG、总2HG以及D/L比值（D-2HG/L-2HG）显著高于对照组。预测IDH突变的100%敏感性（特异性91%-94%）的最佳截断值为：D-2HG>588 ng/mL，D/L比值>2.33。我们的研究表明，血清D-2HG和D/L比值升高可能作为AML中IDH突变的非侵入性生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad5/10435681/3ba403209441/JHA2-4-723-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad5/10435681/0d759b11a6da/JHA2-4-723-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad5/10435681/3ba403209441/JHA2-4-723-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad5/10435681/0d759b11a6da/JHA2-4-723-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad5/10435681/3ba403209441/JHA2-4-723-g002.jpg

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2
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Leukemia. 2015 Dec;29(12):2421-3. doi: 10.1038/leu.2015.151. Epub 2015 Jun 19.
3
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Front Oncol. 2024 Aug 5;14:1413264. doi: 10.3389/fonc.2024.1413264. eCollection 2024.
L-2-羟基戊二酸：一种肾癌中的表观遗传修饰剂和假定的致癌代谢物。
Cancer Discov. 2014 Nov;4(11):1290-8. doi: 10.1158/2159-8290.CD-13-0696. Epub 2014 Sep 2.
4
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J Clin Oncol. 2014 Feb 1;32(4):297-305. doi: 10.1200/JCO.2013.50.2047. Epub 2013 Dec 16.
5
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8
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9
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Oncogene. 2012 May 10;31(19):2491-8. doi: 10.1038/onc.2011.416. Epub 2011 Sep 26.
10
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Cancer Cell. 2010 Dec 14;18(6):553-67. doi: 10.1016/j.ccr.2010.11.015. Epub 2010 Dec 9.