Xue Owen, Curry Choladda V, Fang Hong, Bueso-Ramos Carlos E, Medeiros L Jeffrey, Wang Wei
Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA.
Department of Pathology Baylor College of Medicine and Texas Children's Hospital Houston Texas USA.
EJHaem. 2023 Jul 3;4(3):837-840. doi: 10.1002/jha2.753. eCollection 2023 Aug.
Acute leukemia with rearrangement shows a spectrum of immunophenotypic presentation, but blastic plasmacytoid dendritic cell differentiation is extremely rare. Here we present a case of rearranged acute leukemia with a hybrid immunophenotype in which a single blast population showed both blastic plasmacytoid dendritic cell and monocytic differentiation. This unusual case contributes to the diversity of the immunophenotypic spectrum in KMT2A rearranged acute leukemia and also sheds light on the cell of origin of plasmacytoid dendritic cells.
伴有重排的急性白血病呈现出一系列免疫表型表现，但原始浆细胞样树突状细胞分化极为罕见。在此，我们报告一例伴有混合免疫表型的KMT2A重排急性白血病病例，其中单个原始细胞群体同时表现出原始浆细胞样树突状细胞和单核细胞分化。这一罕见病例丰富了KMT2A重排急性白血病免疫表型谱的多样性，也为浆细胞样树突状细胞的起源细胞提供了线索。
