Melchiorre Giulia, Giustiniano Francesco, Rathore Sundeep, Pileio Giuseppe
School of Chemistry, University of Southampton, Southampton, United Kingdom.
Front Chem. 2023 Aug 4;11:1224336. doi: 10.3389/fchem.2023.1224336. eCollection 2023.
In this study, long-lived nuclear singlet order methods are combined with diffusion tensor imaging with the purpose of characterizing the full diffusion tensor of molecules diffusing freely in large pores of up to a millimeter in size. Such sizes are out of reach in conventional diffusion tensor imaging because of the limitations imposed by the relaxation decay constant of the longitudinal magnetization. A singlet-assisted diffusion tensor imaging methodology able to circumvent such limitations is discussed, and the new possibilities that it offers are demonstrated through simulation and experiments on plastic phantoms containing cylindrical channels of 1 mm in diameter.
在本研究中，长寿命核单重态序方法与扩散张量成像相结合，目的是表征在尺寸达一毫米的大孔隙中自由扩散的分子的完整扩散张量。由于纵向磁化弛豫衰减常数所带来的限制，这样的尺寸在传统扩散张量成像中是无法实现的。本文讨论了一种能够规避此类限制的单重态辅助扩散张量成像方法，并通过对含有直径1毫米圆柱形通道的塑料模型进行模拟和实验，展示了该方法所带来的新可能性。
