Klein S, Young V R, Blackburn G L, Bistrian B R, Wolfe R R
J Clin Invest. 1986 Oct;78(4):928-33. doi: 10.1172/JCI112682.
Data obtained in vitro suggest that the ability to mobilize fat decreases with age. We determined lipolytic rates in vivo in normal weight young adult (22-33 yr) and elderly (65-77 yr) subjects using a simultaneous infusion of [1,2-13C2]palmitate and [2H5]glycerol. The subjects were studied after a 12-h fast and again after 60-82 h of fasting. When lipolysis was expressed per unit of adipose tissue the values for the young adults were more than double those for the elderly (P less than 0.05). However, the amount of body fat in the elderly was twice that of the young adults, so that lipolysis per unit of body weight was similar in both groups. These results demonstrate that lipolysis per unit of adipose tissue is lower in elderly subjects. This may be due to their increase in body fat, however, since the total amount of potential energy mobilized from adipose tissue was similar to that of the young adults.
体外获得的数据表明，脂肪动员能力会随着年龄增长而下降。我们通过同时输注[1,2-¹³C₂]棕榈酸酯和[²H₅]甘油，测定了正常体重的年轻成年人（22 - 33岁）和老年人（65 - 77岁）体内的脂肪分解率。在禁食12小时后以及禁食60 - 82小时后对受试者进行研究。当按单位脂肪组织来表示脂肪分解时，年轻成年人的值是老年人的两倍多（P < 0.05）。然而，老年人的体脂量是年轻成年人的两倍，因此两组中每单位体重的脂肪分解相似。这些结果表明，老年受试者每单位脂肪组织的脂肪分解较低。不过，这可能是由于他们体脂增加所致，因为从脂肪组织中动员的潜在能量总量与年轻成年人相似。
