Kirsch John P, Nottoli Madeline M, Findakly Dawood, Wang Jue
Internal Medicine, Creighton University School of Medicine, Phoenix, USA.
Hematology and Oncology, Louisiana State University Health Shreveport, Shreveport, USA.
Cureus. 2023 Jul 19;15(7):e42123. doi: 10.7759/cureus.42123. eCollection 2023 Jul.
Cogan's syndrome (CS) is a rare disorder of an unknown origin characterized by inflammatory eye disease and vestibuloauditory symptoms, primarily affecting young white adults, without a hereditary pattern. The exclusion of other diseases makes diagnosis difficult, and it is likely underreported in the literature. A 74-year-old previously healthy African American male presented with ear and jaw pain, later accompanied by vestibular symptoms, fever of unknown origin, aortitis, and a third-degree heart block. The workup revealed incidental renal cell carcinoma and interstitial keratitis. This case highlights the challenge of diagnosing an atypical presentation of CS with late-onset interstitial keratitis by excluding other complex syndromes.
科根综合征（CS）是一种病因不明的罕见疾病，其特征为眼部炎症性疾病和前庭听觉症状，主要影响年轻白人成年人，无遗传模式。排除其他疾病会使诊断变得困难，且该疾病在文献中的报道可能不足。一名74岁、既往健康的非裔美国男性出现耳部和下颌疼痛，随后伴有前庭症状、不明原因发热、主动脉炎和三度心脏传导阻滞。检查发现了偶然的肾细胞癌和间质性角膜炎。该病例凸显了通过排除其他复杂综合征来诊断伴有迟发性间质性角膜炎的CS非典型表现的挑战。
