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多发性面部基底细胞癌伴着色性干皮病。

Multiple Facial Basal Cell Carcinoma With Xeroderma Pigmentosum.

机构信息

Plastic Surgery Institute, Weifang Medical University, Weifang.

Shandong Provincial Institute of Dermatology, Venereology, Jinan, Shandong, P.R. China.

出版信息

J Craniofac Surg. 2023;34(8):e761-e762. doi: 10.1097/SCS.0000000000009642. Epub 2023 Aug 21.

Abstract

Multiple basal cell carcinomas are rare in children and adolescents. Xeroderma pigmentosum (XP) is a rare autosomal recessive hereditary disease characterized by photosensitivity, changes in skin pigmentation, and early onset of skin cancer. XP is extremely rare in clinical practice, with only a few cases worldwide. XP is clinically incurable. The main goal of treating this disease is to diagnose as early as possible, educate patients to strictly avoid ultraviolet radiation for life, and follow up regularly to treat skin malignant tumors in time. The authors report a 15-year-old boy with facial multiple basal cell carcinoma with XP. Its medical history, clinical features, auxiliary examination, and surgical treatment process have great reference value for the in-depth understanding of the disease. The authors will discuss how to delay the progression of the disease and treat the existing lesions in different clinical stages of the disease in combination with the existing relevant literature.

摘要

多发性基底细胞癌在儿童和青少年中较为罕见。着色性干皮病(XP)是一种罕见的常染色体隐性遗传性疾病,其特征为光敏感性、皮肤色素改变和皮肤癌的早期发病。XP 在临床实践中极为罕见,全世界仅有少数几例。XP 无法临床治愈。治疗这种疾病的主要目标是尽早诊断,教育患者终生严格避免紫外线辐射,并定期随访以及时治疗皮肤恶性肿瘤。作者报告了一例 XP 合并面部多发性基底细胞癌的 15 岁男孩。其病史、临床特征、辅助检查和手术治疗过程对深入了解该疾病具有重要的参考价值。作者将结合现有相关文献,讨论如何在疾病的不同临床阶段延迟疾病进展和治疗现有病变。

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