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面部基底细胞癌患者整形手术及修复效果预测模型的构建

Construction of a predictive model for the effectiveness of plastic surgery and repair in patients with facial basal cell carcinoma.

作者信息

Wu Lijun, Tang Shuhan, Jiang Jingting, Li Ke

机构信息

Department of Burn and Plastic Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu, China.

Department of Plastic and Aesthetic Surgery, The Second Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu, China.

出版信息

Am J Cancer Res. 2024 Dec 15;14(12):5798-5811. doi: 10.62347/VWMD6054. eCollection 2024.

Abstract

This study aims to identify factors influencing aesthetic outcomes following facial basal cell carcinoma (BCC) plastic surgery to enhance post-operative satisfaction and cosmetic results. A retrospective cohort study was conducted on 303 patients who underwent facial BCC plastic surgery between June 2021 and June 2023. Data on demographics, blood tests, SF-12, and Skindex-16 scores were analyzed. Patients were categorized into satisfactory and unsatisfactory outcome groups based on post-operative assessments. The training set of patients was sourced from the Third Affiliated Hospital of Soochow University, while the testing set of patients was sourced from the First Affiliated Hospital of Soochow University. Of 209 patients, 116 were in the satisfactory group, 93 in the unsatisfactory. Factors enhancing positive outcomes included reconstruction methods ( < 0.001) and smaller tumor diameters ( = 0.006). Higher pre-op 12-item Short Form Survey (SF-12) scores correlated with better outcomes ( = 0.005). Lower Skindex-16 scores were noted in the satisfactory group (P < 0.001). Logistic regression highlighted reconstruction method, aging signs, SF-12 scores, and Skindex-16 as key predictors. A random forest model achieved an area under the curve (AUC) of 0.984. External validation confirmed similar associations with satisfactory outcomes (AUC = 0.870). Aesthetic outcomes in facial BCC plastic surgery are influenced by reconstruction method and tumor diameter, patient health status (SF-12), and skin-related quality of life (Skindex-16). Personalized surgical planning and comprehensive care are essential for optimizing outcomes.

摘要

本研究旨在确定影响面部基底细胞癌(BCC)整形手术后美学效果的因素,以提高术后满意度和美容效果。对2021年6月至2023年6月期间接受面部BCC整形手术的303例患者进行了回顾性队列研究。分析了人口统计学、血液检查、SF - 12和Skindex - 16评分的数据。根据术后评估将患者分为满意和不满意结果组。患者训练集来自苏州大学附属第三医院,而患者测试集来自苏州大学附属第一医院。在209例患者中,116例在满意组,93例在不满意组。提高积极结果的因素包括重建方法(<0.001)和较小的肿瘤直径(=0.006)。术前12项简短形式调查(SF - 12)评分越高,结果越好(=0.005)。满意组的Skindex - 16评分较低(P<0.001)。逻辑回归强调重建方法、衰老迹象、SF - 12评分和Skindex - 16是关键预测因素。随机森林模型的曲线下面积(AUC)为0.984。外部验证证实与满意结果有类似关联(AUC = 0.870)。面部BCC整形手术的美学效果受重建方法、肿瘤直径、患者健康状况(SF - 12)和皮肤相关生活质量(Skindex - 16)影响。个性化手术规划和综合护理对于优化结果至关重要。

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本文引用的文献

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JPRAS Open. 2024 Aug 23;42:97-112. doi: 10.1016/j.jpra.2024.08.004. eCollection 2024 Dec.
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