Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand; Musculoskeletal Science and Translational Research (MSTR) Center, Department of Orthopedics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Environ Toxicol Pharmacol. 2023 Sep;102:104252. doi: 10.1016/j.etap.2023.104252. Epub 2023 Aug 20.
Glyphosate-based herbicides (GBHs) containing glyphosate as the active component are extensively used worldwide. Concerns have arisen about their potential risk to human, as glyphosate has been detected in human body fluids. Current controversies surround the endocrine-disrupting properties and transgenerational inheritance of diseases and germline epimutations resulting from exposure to GBHs and glyphosate. This review discusses evidence from in vitro, in vivo, and clinical studies on their impact on sex hormone regulation and reproductive system. Evidence suggests that they act as endocrine-disrupting chemicals, which altering sex hormone levels. Mechanistically, they interfere with hormone signaling pathways by disrupting proteins involved in hormone transport and metabolism. Pathological changes have been observed in male and female reproductive systems, potentially leading to reproductive toxicity. Prenatal exposure may lead to transgenerational inheritance of pathologies and sperm epimutations. However, due to the complexity of glyphosate formulations containing adjuvants identifying higher risk components in environmental exposure becomes challenging.
草甘膦基除草剂（GBHs）含有草甘膦作为活性成分，在全球范围内广泛使用。由于在人体体液中检测到草甘膦，人们对其对人类的潜在风险产生了担忧。目前围绕着接触草甘膦基除草剂和草甘膦可能导致疾病的内分泌干扰特性和跨代遗传以及生殖系表突变存在争议。本综述讨论了来自体外、体内和临床研究的证据，这些研究涉及它们对性激素调节和生殖系统的影响。有证据表明，它们作为内分泌干扰化学物质，改变性激素水平。从机制上讲，它们通过干扰参与激素运输和代谢的蛋白质来干扰激素信号通路。已经观察到男性和女性生殖系统的病理变化，可能导致生殖毒性。产前暴露可能导致生殖毒性和精子表突变的跨代遗传。然而，由于含有助剂的草甘膦配方的复杂性，在环境暴露中确定更高风险的成分变得具有挑战性。
