Animal Endocrine and Reproductive Physiology Laboratory, Department of Physiology, Sector of Biological Sciences, Federal University of Paraná, Curitiba, Brazil.
Reproductive Toxicology Laboratory, Department of Pharmacology, Sector of Biological Sciences, Federal University of Paraná, Curitiba, Brazil.
Front Endocrinol (Lausanne). 2021 Mar 15;12:627210. doi: 10.3389/fendo.2021.627210. eCollection 2021.
Glyphosate-based herbicides (GBHs) are among the most used pesticides worldwide, presenting high potential for human exposure. Recently, a debate was raised on glyphosate risks to human health due to conflicting views over its potential carcinogenic and endocrine disruptive properties. Results from regulatory guideline studies, reports from Regulatory Agencies, and some literature studies point to a lack of endocrine disrupting properties of the active ingredient glyphosate. On the other hand, many and studies, using different experimental model systems, have demonstrated that GBHs can disrupt certain hormonal signaling pathways with impacts on the hypothalamic-pituitary-gonadal axis and other organ systems. Importantly, several studies showed that technical-grade glyphosate is less toxic than formulated GBHs, indicating that the mixture of the active ingredient and formulants can have cumulative effects on endocrine and reproductive endpoints, which requires special attention from Regulatory Agencies. In this mini-review, we discuss the controversies related to endocrine-disrupting properties of technical-grade glyphosate and GBHs emphasizing the reproductive system and its implications for human health.
草甘膦类除草剂（GBHs）是世界上使用最广泛的农药之一，具有很高的人体暴露风险。最近，由于对其潜在致癌和内分泌干扰特性存在不同看法，人们对草甘膦对人类健康的风险展开了争论。监管指导原则研究的结果、监管机构的报告以及一些文献研究表明，草甘膦活性成分没有内分泌干扰特性。另一方面，许多体内和体外研究使用不同的实验模型系统，证明了 GBHs 可以破坏某些激素信号通路，对下丘脑-垂体-性腺轴和其他器官系统产生影响。重要的是，几项研究表明，技术级草甘膦的毒性低于配制的 GBHs，这表明活性成分和制剂的混合物会对内分泌和生殖终点产生累积影响，这需要监管机构的特别关注。在这篇迷你综述中，我们讨论了与技术级草甘膦和 GBHs 的内分泌干扰特性相关的争议，重点讨论了生殖系统及其对人类健康的影响。
