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Deposition of complement components C5b-9 and MASP2 in tissues is not a feature of GVHD and may assist in discriminating GVHD from thrombotic microangiopathy following allogenic transplantation.

作者信息

Alhomoud Mohammad, Magro Cynthia, Seshan Surya, Zhang Taotao, Gomez-Arteaga Alexandra, Chokr Nora, Yamshon Samuel, Phillips Adrienne, Mayer Sebastian, Shore Tsiporah, Laurence Jeffrey

机构信息

Division of Hematology and Oncology, Department of Medicine, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY, USA.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

出版信息

Bone Marrow Transplant. 2023 Nov;58(11):1270-1274. doi: 10.1038/s41409-023-02089-y. Epub 2023 Aug 21.

DOI:10.1038/s41409-023-02089-y
PMID:37604872
Abstract
摘要

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Deposition of complement components C5b-9 and MASP2 in tissues is not a feature of GVHD and may assist in discriminating GVHD from thrombotic microangiopathy following allogenic transplantation.补体成分C5b-9和甘露聚糖结合凝集素相关丝氨酸蛋白酶2（MASP2）在组织中的沉积不是移植物抗宿主病（GVHD）的特征，可能有助于将GVHD与同种异体移植后的血栓性微血管病区分开来。
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C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy.C5b-9和MASP2在皮肤和骨髓微血管系统中的沉积是造血干细胞移植相关血栓性微血管病的特征。
Bone Marrow Transplant. 2022 Sep;57(9):1445-1447. doi: 10.1038/s41409-022-01723-5. Epub 2022 Jun 4.
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Plasma levels of complement activation fragments C3b and sC5b-9 significantly increased in patients with thrombotic microangiopathy after allogeneic stem cell transplantation.在异基因干细胞移植后的血栓性微血管病患者中，补体激活片段C3b和sC5b-9的血浆水平显著升高。
Ann Hematol. 2017 Nov;96(11):1849-1855. doi: 10.1007/s00277-017-3092-9. Epub 2017 Aug 11.
4
[Changes in diagnostic criteria of thrombotic microangiopathy after stem cell transplantation].[干细胞移植后血栓性微血管病诊断标准的变化]
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Complement-mediated thrombotic microangiopathy as a link between endothelial damage and steroid-refractory GVHD.补体介导的血栓性微血管病作为内皮损伤与激素难治性移植物抗宿主病之间的联系。
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MASP2 levels are elevated in thrombotic microangiopathies: association with microvascular endothelial cell injury and suppression by anti-MASP2 antibody narsoplimab.血栓性微血管病中 MASP2 水平升高：与微血管内皮细胞损伤相关，并被抗 MASP2 抗体 narsoplimab 抑制。
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Tohoku J Exp Med. 2012 May;227(1):31-7. doi: 10.1620/tjem.227.31.
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Linking Complement Activation, Coagulation, and Neutrophils in Transplant-Associated Thrombotic Microangiopathy.在移植相关性血栓性微血管病中补体激活、凝血和中性粒细胞的关系。
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Severe diarrhea following bone marrow transplantation is not always caused by GVHD.
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本文引用的文献

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Chemotherapy-induced complement signaling modulates immunosuppression and metastatic relapse in breast cancer.化疗诱导的补体信号转导调节乳腺癌的免疫抑制和转移复发。
Nat Commun. 2022 Oct 2;13(1):5797. doi: 10.1038/s41467-022-33598-x.
2
C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy.C5b-9和MASP2在皮肤和骨髓微血管系统中的沉积是造血干细胞移植相关血栓性微血管病的特征。
Bone Marrow Transplant. 2022 Sep;57(9):1445-1447. doi: 10.1038/s41409-022-01723-5. Epub 2022 Jun 4.
3
Premortem Skin Biopsy Assessing Microthrombi, Interferon Type I Antiviral and Regulatory Proteins, and Complement Deposition Correlates with Coronavirus Disease 2019 Clinical Stage.
生前皮肤活检测定微血栓、Ⅰ型干扰素抗病毒和调节蛋白及补体沉积与 2019 年冠状病毒病临床分期相关。
Am J Pathol. 2022 Sep;192(9):1282-1294. doi: 10.1016/j.ajpath.2022.05.006. Epub 2022 May 28.
4
Refractory acute graft-versus-host disease: a new working definition beyond corticosteroid refractoriness.难治性急性移植物抗宿主病：超越激素抵抗的新工作定义。
Blood. 2020 Oct 22;136(17):1903-1906. doi: 10.1182/blood.2020007336.
5
MASP2 levels are elevated in thrombotic microangiopathies: association with microvascular endothelial cell injury and suppression by anti-MASP2 antibody narsoplimab.血栓性微血管病中 MASP2 水平升高：与微血管内皮细胞损伤相关，并被抗 MASP2 抗体 narsoplimab 抑制。
Clin Exp Immunol. 2021 Jan;203(1):96-104. doi: 10.1111/cei.13497. Epub 2020 Aug 5.
6
An Update in Drug-Induced Thrombotic Microangiopathy.药物性血栓性微血管病的最新进展
Front Med (Lausanne). 2020 May 22;7:212. doi: 10.3389/fmed.2020.00212. eCollection 2020.
7
Complement-mediated thrombotic microangiopathy as a link between endothelial damage and steroid-refractory GVHD.补体介导的血栓性微血管病作为内皮损伤与激素难治性移植物抗宿主病之间的联系。
Blood Adv. 2018 Oct 23;2(20):2619-2628. doi: 10.1182/bloodadvances.2018020321.
8
Diagnostic Utility of Complement Immunohistochemical Studies in Post-Stem Cell Transplant Intestinal Thrombotic Microangiopathy: Case Report.
J Pediatr Hematol Oncol. 2017 May;39(4):282-286. doi: 10.1097/MPH.0000000000000729.
9
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.美国国立卫生研究院慢性移植物抗宿主病临床试验标准共识发展项目：I. 2014年诊断与分期工作组报告
Biol Blood Marrow Transplant. 2015 Mar;21(3):389-401.e1. doi: 10.1016/j.bbmt.2014.12.001. Epub 2014 Dec 18.
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Complement component C3 mediates Th1/Th17 polarization in human T-cell activation and cutaneous GVHD.补体成分C3在人T细胞活化和皮肤移植物抗宿主病中介导Th1/Th17极化。
Bone Marrow Transplant. 2014 Jul;49(7):972-6. doi: 10.1038/bmt.2014.75. Epub 2014 Apr 28.