Department of Chemical Engineering, Faculty of Engineering, Arak University, Arak, 38156-88349, Iran.
Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Sci Rep. 2023 Aug 21;13(1):13560. doi: 10.1038/s41598-023-40627-2.
Successful cancer treatment using magnetic hyperthermia therapy (MHT) strongly depends on biocompatible magnetic nanoparticles (NPs). They can effectively accumulate in tumor tissues after systemic injection and generate heat in the therapeutic temperature range (42-48 °C) by exposure to an AC magnetic field (AMF). For this purpose, folic acid-conjugated dextran-coated ZnMnFeO (FA-Dex-ZMF) NPs were synthesized as smart nano heaters with self-regulating temperatures for MHT of liver tumors. Animal studies on BALB/c mice showed that the prepared NPs did not cause acute toxicity upon administration up to 100 mg kg. Likewise, no significant changes in hematological and biochemical factors were observed. FA-Dex-ZMF NPs were studied by exposing them to different safe AC magnetic fields (f = 150 kHz, H = 6, 8, and 10 kA m). Calorimetric experiments revealed that the NPs reached the desired temperature range (42-48 °C), which was suitable for MHT. Moreover, the efficacy of FA-Dex-ZMF NPs in MHT of liver tumors was investigated in vivo in liver-tumor-bearing mice. The obtained results revealed that the average volume of tumors in the control group increased 2.2 times during the study period. In contrast, the tumor volume remained almost constant during treatment in the MHT group. The results indicated that folic acid-conjugated dextran-coated ZnMnFeO NPs with self-regulating temperature could be a promising tool for systemically delivered MHT.
使用磁热疗（MHT）成功治疗癌症强烈依赖于生物相容性的磁性纳米粒子（NPs）。它们可以在全身注射后有效地在肿瘤组织中积累，并通过暴露于交流磁场（AMF）在治疗温度范围内（42-48°C）产生热量。为此，合成了叶酸偶联葡聚糖包覆的 ZnMnFeO（FA-Dex-ZMF） NPs 作为智能纳米加热器，用于肝癌的 MHT，具有自调节温度的特性。BALB/c 小鼠的动物研究表明，在高达 100 mg kg 的剂量下给药时，所制备的 NPs 不会引起急性毒性。同样，血液学和生化因子也没有明显变化。通过将 FA-Dex-ZMF NPs 暴露于不同安全的交流磁场（f=150 kHz，H=6、8 和 10 kA m）来研究它们。量热实验表明， NPs 达到了所需的温度范围（42-48°C），适用于 MHT。此外，还在荷肝癌小鼠体内研究了 FA-Dex-ZMF NPs 在肝癌 MHT 中的疗效。结果表明，在研究期间，对照组肿瘤的平均体积增加了 2.2 倍。相比之下，在 MHT 组的治疗过程中，肿瘤体积几乎保持不变。结果表明，具有自调节温度的叶酸偶联葡聚糖包覆的 ZnMnFeO NPs 可能是一种有前途的用于系统输送 MHT 的工具。
