Department of Physics, Faculty of Science, Arak University, Arak 38156-88349, Iran; Institute of Nanoscience and Nanotechnology, Arak university, Arak, Iran.
Department of Physics, Faculty of Science, Arak University, Arak 38156-88349, Iran; Institute of Nanoscience and Nanotechnology, Arak university, Arak, Iran.
Mater Sci Eng C Mater Biol Appl. 2020 Dec;117:111274. doi: 10.1016/j.msec.2020.111274. Epub 2020 Jul 7.
A precise control of the particle size of dextran-coated magnetite nanoparticles (Dex-M NPs) was successfully performed by combination of co-precipitation and hydrothermal synthesis methods. The Dex-M NPs, in the size range 3.1-18.9 nm, were used to fabricate biocompatible magnetic fluids for application in magnetic hyperthermia therapy (MHT). The effects of the carrier fluid viscosity, particle size, and applied magnetic field strength (H) on the specific loss power (SLP) of the Dex-M NPs were investigated at a fixed magnetic field frequency (f). The experimental results show that SLP of the larger Dex-M NPs significantly decreases for a highly viscous carrier fluid. Moreover, regardless of the carrier fluid viscosity, the particle size strongly affects the heating efficiency of the Dex-M NPs. SLP ranges from zero for the smallest Dex-M NPs (with particle size d = 3.1 nm) to 55.21 W/g for the largest ones (d = 18.9 nm) at H = 28 kA/m and f = 120 kHz. The most important finding in our research is that, at a fixed frequency, the optimal size of the Dex-M NPs (the size that maximizes SLP) shows a rising trend by enhancing H. In fact, the highest values of SLP at H = 11 kA/m, 13 - 17.5 kA/m, and 19 - 28 kA/m are obtained for the Dex-M NPs with d = 11.5 nm, 15 nm, and 18.9 nm, respectively. The shift of optimal size to the higher values by increasing H could shed light on the correlated effects of the particle size and H on the heating efficiency of magnetic nanoparticles (MNPs) and pave a new way toward the better tuning of them for an effective and biologically safe treatment.
通过共沉淀和水热合成方法的结合，成功地对葡聚糖包覆的磁铁矿纳米粒子（Dex-M NPs）的粒径进行了精确控制。所制备的 Dex-M NPs 的粒径在 3.1-18.9nm 范围内，用于制备用于磁热疗（MHT）的生物相容性磁性流体。在固定磁场频率（f）下，研究了载体流体粘度、粒径和外加磁场强度（H）对 Dex-M NPs 比损耗功率（SLP）的影响。实验结果表明，对于高粘度的载体流体，较大的 Dex-M NPs 的 SLP 显著降低。此外，无论载体流体的粘度如何，粒径强烈影响 Dex-M NPs 的加热效率。在 H=28 kA/m 和 f=120 kHz 下，SLP 范围从零（粒径最小的 Dex-M NPs，d=3.1nm）到最大的 Dex-M NPs（d=18.9nm）为 55.21 W/g。我们研究的最重要的发现是，在固定频率下，Dex-M NPs 的最佳粒径（使 SLP 最大化的粒径）随 H 的增强呈上升趋势。实际上，在 H=11 kA/m、13-17.5 kA/m 和 19-28 kA/m 时，分别获得了 SLP 最高值的 Dex-M NPs 的粒径为 11.5nm、15nm 和 18.9nm。通过增加 H 使最佳粒径向更高值移动，可以揭示粒径和 H 对磁性纳米粒子（MNPs）加热效率的相关影响，并为更好地调整 MNPs 以实现有效和生物安全的治疗开辟新途径。
