Kiesel U, Maruta K, Treichel U, Bicker U, Kolb H
J Immunopharmacol. 1986;8(3):393-406. doi: 10.3109/08923978609026496.
BB rats spontaneously develop an insulin dependent diabetes which resembles in many features human type I diabetes. We have tested the effect of the immunomodulatory drug Ciamexone, a 2-cyan-aziridine-derivative, on the development of diabetes in BB rats. Ciamexone was given once daily during 6 days per week beginning with the age of 42 or 50 days up to 120 days. For comparison cyclosporin A (10 mg/kg) was applied following the same protocol. At 1 mg/kg ciamexone administration led to complete prevention of diabetes in females but was not beneficial in males. At 10 mg/kg the drug caused significant suppression of diabetes development in males but more pronounced in females. Both, a reduction of the incidence of diabetes and a delay in the onset of hyperglycaemia was observed only in females. After administration of cyclosporin A none of the animals developed diabetes. Ciamexone treatment did not affect granulocyte and lymphocyte counts and subsets in the peripheral blood except for a tendency to suppress eosinophilia. The growth of animals was not retarded. It is concluded that ciamexone seems to influence the autoimmune state of the BB rat resulting in partial suppression of the disease.
BB大鼠会自发发展出一种胰岛素依赖型糖尿病，其在许多特征上与人类I型糖尿病相似。我们测试了免疫调节药物Ciamexone（一种2-氰基氮丙啶衍生物）对BB大鼠糖尿病发展的影响。从42或50日龄开始至120日龄，每周6天每天给药一次Ciamexone。作为对照，按照相同方案应用环孢素A（10毫克/千克）。给予1毫克/千克的Ciamexone可完全预防雌性大鼠患糖尿病，但对雄性大鼠无效。给予10毫克/千克时，该药物可显著抑制雄性大鼠糖尿病的发展，但对雌性大鼠的作用更明显。仅在雌性大鼠中观察到糖尿病发病率降低和高血糖症发作延迟。给予环孢素A后，没有动物发展为糖尿病。Ciamexone治疗除了有抑制嗜酸性粒细胞增多的趋势外，不影响外周血中的粒细胞和淋巴细胞计数及亚群。动物的生长未受阻碍。得出的结论是，Ciamexone似乎会影响BB大鼠的自身免疫状态，从而部分抑制该疾病。
