氯胺酮对BB/Wor大鼠淋巴细胞性甲状腺炎和胰岛素依赖型糖尿病的影响。
The effect of ciamexone on lymphocytic thyroiditis and insulin-dependent diabetes mellitus in the BB/Wor rat.
作者信息
Abend S, Cormier J, Appel M C, Lueprasitsakul W, Alex S, Mordes J P, Usadel K H, Handler E S, Rossini A A, Braverman L E
机构信息
Department of Medicine, University of Massachusetts Medical School, Worcester 01655.
出版信息
Immunopharmacology. 1990 May-Jun;19(3):163-8. doi: 10.1016/0162-3109(90)90065-m.
Previous studies have suggested that ciamexone, a 2-cyan-aziridine derivative, is a selective immunomodulatory agent with potential therapeutic application in a variety of autoimmune diseases. In the present study, the effects of ciamexone on autoimmune lymphocytic thyroiditis and diabetes mellitus were studied in the BB rat. The data suggest that, in this animal model, ciamexone does not affect the frequency of autoimmune diabetes or lymphocytic thyroiditis nor does it affect the serum TSH or T4 concentrations.
先前的研究表明，西阿美酮（一种2-氰基氮丙啶衍生物）是一种选择性免疫调节剂，在多种自身免疫性疾病中具有潜在的治疗应用价值。在本研究中，在BB大鼠中研究了西阿美酮对自身免疫性淋巴细胞性甲状腺炎和糖尿病的影响。数据表明，在这种动物模型中，西阿美酮不影响自身免疫性糖尿病或淋巴细胞性甲状腺炎的发生率，也不影响血清促甲状腺激素（TSH）或甲状腺素（T4）浓度。
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